Comparison of thyroid hormone profile (T3, T4, TSH, ANTI TPOAB, & TBG) among fertile and infertile females.

Abstract

Objective: To compare thyroid hormone profile (T3, T4, TSH, Anti TPOAb, & TBG) among fertile and infertile females. Study Design: Case-control study. Setting: Department of Physiology and Department of Gynecology and Obstetrics, JPMC Karachi, BMSI. Period: Jan 2018 to Jan 2019. Material & Methods: There were 88 participants in the sample, who were split into two groups. Infertile group (group A) and control group (group B). Non-probability purposive sampling was employed because each group's subjects were chosen based on specified standards. In the current investigation, all subjects who met the eligibility requirements were registered. Each subject who took part gave their written consent. Information obtained was held in strict confidence. Data was analyzed using IBM SPSS version 23. Results: Serum T3, T4, TSH, anti TPOAb, and TBG levels differed significantly between the two study groups. There was significant mean difference obtained for TSH and anti TPO antibodies between fertile and infertile samples with p-value less than 0.05. Conclusion: In this study, all the subjects had T3, T4, TSH & TBG levels within the normal pre-pregnancy reference range. A trend towards subclinical hypothyroidism and the incidence of anti-thyroid antibodies was observed within females who had UE infertility, when their thyroid hormone profile was compared with fertile females.