FIB-4 INDEX:

DIAGNOSTIC VALIDITY FOR PREDICTING HEPATIC FIBROSIS IN SOUTH EAST ASIAN PATIENTS OF CHRONIC HEPATITIS C VIRUS (HCV) GENOTYPE 3 INFECTION

Authors

  • Fida Hussain Shaikh Isra University Hospital (IUH) Hyderabad.
  • Shaista Zeb Gastroenterology, (IUH) Hyderabad.
  • Kashif Aziz Siddiqui (IUH) Hyderabad.
  • Muhammad Aamir Ghori (IUH) Hyderabad.
  • Muhammad Sadik Memon (IUH) Hyderabad.
  • Madiha Zaki (IUH) Hyderabad.

DOI:

https://doi.org/10.29309/TPMJ/2017.24.10.703

Keywords:

Liver biopsy,, Metavir,, Non-invasive,, Cirrhosis,, Fibrosis,, Pakistan.

Abstract

Objectives: To assess the diagnostic validity of FIB-4 for predicting hepatic
fibrosis in patients of chronic hepatitis C genotype 3. Study Design: Cross-sectional study.
Setting: Department of Gastroenterology and Hepatology, Isra University Hospital, Hyderabad
through convenient sampling. Period: June 2013 to June 2014. Methods: Diagnostic validity of
FIB-4 index for predicting hepatic fibrosis was determined by measuring sensitivity, specificity,
positive productive, negative predictive value, and compared these parameters with liver
biopsy. The liver histology was determined by METAVIR score. Results: A total 115 patients
were enrolled with mean and SD of age was 39.6 ± 9.3 years. Dividing FIB-4 index into three
categories as <1.45, 1.45 - 3.25, and >3.25; by using the Obuchowski method the AUROC was
0.93 (with 95% CI 0.91, 0.95). When dividing the FIB-4 index in to three categories as <1.45,
1.45 - <2.25 and >2.25; the AUROC by using Obuchowski method was 0.87 (with 95% CI 0.83,
0.91). Similarly for the diagnosis of Cirrhosis (F = 4 METAVIR) on the predictive value of the
non-invasive test FIB-4 while using Obuchowski method the AUROC was 0.85 (with 95% CI
0.83, 0.87). Conclusion: The FIB-4 index is a simple, inexpensive, non-invasive, and a quick
test for predicting liver fibrosis in patients of chronic Hepatitis C genotype 3.

Author Biographies

Fida Hussain Shaikh, Isra University Hospital (IUH) Hyderabad.

FCPS (Medicine)
Professor, Department of Medicine

Shaista Zeb, Gastroenterology, (IUH) Hyderabad.

FCPS (Gastroenterology)
Assistant Professor,
Department of Medicine/

Kashif Aziz Siddiqui, (IUH) Hyderabad.

MBBS, DMRD
Assistant Professor,
Department of Radiology,

Muhammad Aamir Ghori, (IUH) Hyderabad.

FCPS (Medicine), FSPS
(Gastroenterology)
Assistant Professor,
Department of Medicine/
Gastroenterology,

Muhammad Sadik Memon, (IUH) Hyderabad.

FCPS (Medicine),FCPS
(Gastroenterology)
Ex-Professor,
Department of Medicine /
Section of Gastroenterology

Madiha Zaki, (IUH) Hyderabad.

MBBS,
Ex-Research Fellow Section of
Gastroenterology, 

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Published

2017-10-06