DIAGNOSTIC VALIDITY FOR PREDICTING HEPATIC FIBROSIS IN SOUTH EAST ASIAN PATIENTS OF CHRONIC HEPATITIS C VIRUS (HCV) GENOTYPE 3 INFECTION
Keywords:Liver biopsy,, Metavir,, Non-invasive,, Cirrhosis,, Fibrosis,, Pakistan.
Objectives: To assess the diagnostic validity of FIB-4 for predicting hepatic
fibrosis in patients of chronic hepatitis C genotype 3. Study Design: Cross-sectional study.
Setting: Department of Gastroenterology and Hepatology, Isra University Hospital, Hyderabad
through convenient sampling. Period: June 2013 to June 2014. Methods: Diagnostic validity of
FIB-4 index for predicting hepatic fibrosis was determined by measuring sensitivity, specificity,
positive productive, negative predictive value, and compared these parameters with liver
biopsy. The liver histology was determined by METAVIR score. Results: A total 115 patients
were enrolled with mean and SD of age was 39.6 ± 9.3 years. Dividing FIB-4 index into three
categories as <1.45, 1.45 - 3.25, and >3.25; by using the Obuchowski method the AUROC was
0.93 (with 95% CI 0.91, 0.95). When dividing the FIB-4 index in to three categories as <1.45,
1.45 - <2.25 and >2.25; the AUROC by using Obuchowski method was 0.87 (with 95% CI 0.83,
0.91). Similarly for the diagnosis of Cirrhosis (F = 4 METAVIR) on the predictive value of the
non-invasive test FIB-4 while using Obuchowski method the AUROC was 0.85 (with 95% CI
0.83, 0.87). Conclusion: The FIB-4 index is a simple, inexpensive, non-invasive, and a quick
test for predicting liver fibrosis in patients of chronic Hepatitis C genotype 3.