Effect of Corn Silk extracts on Hepatic steatosis in doxorubicin treated Albino Rats.

Abstract

Objectives: To determine hepatoprotective effects of cornsilk extracts through laboratory and histopathological parameters in albino rats. Study Design: Experimental Animal study. Setting: Animal House and Histology Laboratory of Postgraduate Medical Institute (PGMI) Lahore. Period: April 2019 to April 2020. Material & Methods: The study was carried out on 30 albino rats and was divided among three groups having ten rats in each group. Group A was labelled as a control group. Groups B and C were labelled as experimental groups. Cellular steatosis as a histological parameter and ALT and AST levels are measured to access the hepatoprotective effects of corn silk. Results: It was found that the mean AST and ALT were also significantly different among the groups analyzing p-value < 0.001. Fisher’s exact test showed that there was significant difference in the percentage of cellular steatosis among groups. Conclusion: It was found that cornsilk extract can be recommended as a hepatoprotective agent against DOX-induced hepatic damage.