Serum uric acid concentration (SUAC): A useful tool to assess extent and severity of chronic plaque psoriasis in Pakistani population.

  • Hafiz Bashir Ahmed Liaquat University of Medical and Health Sciences, Jamshoro, Sindh.
  • Deepa Mohan Lal Dow University of Health Sciences, Karachi, Sindh.
  • Muhammad Suleman Pirzado Liaquat University of Medical and Health Sciences, Jamshoro, Sindh.
  • Ajmal Rashid Boulevard Hospital, DHA Phase-1, Karachi, Sindh.
  • Irfan Anwar PNS Shifa Hospital, Karachi, Sindh.
  • Sanam Malkani Liaquat University of Medical and Health Sciences, Jamshoro, Sindh.
Keywords: Hyperuricemia, Psoriasis, Serum Uric Acid

Abstract

Objectives: Psoriasis is a systemic chronic inflammatory autoimmune disease. Psoriasis can lead to multiple complications and co-morbidities. It has also been observed that raised serum uric acid levels predispose to gouty arthritis and also thought to be a risk factor for cardiovascular mortality and morbidity. The basic aim of this study was to ascertain level of serum uric acid in patients with chronic plaque psoriasis and control cases which might be a useful tool for assessing the extent and severity of chronic plaque psoriasis. Study Design: Case control study. Setting: At Outpatient’s Department (OPD) of Department of Dermatology, PNS Shifa, Karachi. Period: From January 2013 to December 2016. Material & Methods: One hundred and ninety four (194) patients were taken in this study and 97 patients were biopsy proven cases of psoriasis and 97 other participants included as control cases reporting to OPD with other complaint like acne, hair fall and fungal infections. After written and informed consent, 5ml of venous blood was drawn in sterile syringe and using gel sample tube to see the serum uric acid levels. On the basis of laboratory reports the elevated serum uric acid level in psoriatic versus normal controls was recorded on a pre-designed proforma. Results: There were 54.6% (106/194) male and 45.4% (88/194) female. Elevated serum uric level was 4.5 times (Approximate of 4.46) more common in cases than control group (OR: 4.46 95%CI: 1.83 to 10.91). Conclusion: Raised levels of serum Uric acid have been seen frequently in psoriatic patients. Early treatment for higher levels of serum uric acid might play a critical role in the better treatment of psoriatic patients. These results revealed that serum uric acid concentration (SUAC) of psoriasis may play a vital role in assessing the complex multifactorial etiology of the psoriasis, severity and other possible metabolic factors.

Author Biographies

Hafiz Bashir Ahmed, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh.

FCPS

Assistant Professor

Dermatology Department

 

Deepa Mohan Lal, Dow University of Health Sciences, Karachi, Sindh.

FCPS

Assistant Professor

Dermatology of Department

 

Muhammad Suleman Pirzado, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh.

MBBS, PhD

Assistant Professor

Department of Molecular Biology & Genetics Lab

 

Ajmal Rashid, Boulevard Hospital, DHA Phase-1, Karachi, Sindh.

FCPS (Dermatology)

Consultant

Department of Dermatologist

 

Irfan Anwar, PNS Shifa Hospital, Karachi, Sindh.

FCPS

Assistant Professor

Dermatology of Department

 

Sanam Malkani, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh.

MBBS

Diploma in Dermatology

Consultant Dermatologist

 

Published
2019-11-10