CORONARY ARTERY BYPASS GRAFTING;
VANCOMYCIN INDUCED NEPHROTOXICITY AND OXIDATIVE STRESS IN PATIENTS
DOI:
https://doi.org/10.29309/TPMJ/2017.24.11.664Keywords:
Vancomycin,, Nephrotoxicity,, Oxidative Stress,, Coronary Artery Bypass Grafting,, Reactive Oxygen Species,, Antioxidants,, Satphylococcus Aureus,, Malondialdehyde,, Catalase.Abstract
Objectives: To evaluate effect of vancomycin in producing nephrotoxicity
and oxidative stress in patients undergoing coronary artery bypass grafting. Study design
and technique: Cross-sectional study, convenient sampling. Setting: Faisalabad institute of
cardiology, Faisalabad, Pakistan. Period: 09 months. Material and Methods: Total 50 patients
who were undergoing coronory artery bypass grafting were enrolled in the study based on
convenience sampling after taking consent. Participants received a single dose of vancomycin
(15mg/kg) before coronory artery bypass grafting and then twice a day after surgery for five
days. Blood was collected at day 0, 4 and 7 and checked for serum creatinine, blood urea, blood
urea nitrogen, catalase, melondialdehyde, total oxidant status and total antioxidant capacity
in order to determine vancomycin induced nephrotoxicity and oxidative stress. Results: The
levels of serum creatinine, blood urea and blood urea nitrogen were significantly high at day 4
and 7 as compare to day 0 with p-value 0.001.Serum catalase was significantly decreased at
day 4 and 7 as compare to day 0 with p-value 0.001 while the level of serum melondialdehyde
was increased significantly at day 4 and 7 in comparison with day 0 with p-value 0.01. Total
antioxidant capacity was significantly decreased while total oxidant status was increased at day
4 and 7 in comparison with day 0 with p-value 0.001 each.
