Effect of anemia on HbA1c level in subjects with normal glucose tolerance.

Authors

  • Muhammad Saeed Baqai Medical University Karachi.
  • Iftikhar Ahmed Siddiqui Baqai Medical University Karachi.
  • Asher Fawwad Baqai Medical University Karachi.
  • Anum Butt Baqai Institute of Diabetology and Endocrinology Karachi.
  • Kahkashan Perveen Baqai Medical University Karachi.
  • Ruqaya Nangrejo Baqai Medical University Karachi.
  • Abdul Basit Baqai Institute of Diabetology and Endocrinology Karachi.

DOI:

https://doi.org/10.29309/TPMJ/2021.28.08.6121

Keywords:

Diabetes, Hemoglobin, Iron Deficiency Anemia

Abstract

Objective: To evaluate the effect of iron deficiency anemia (IDA) on HbA1c levels in non-diabetic Pakistani individuals. Study Design: Observational Study. Setting: Baqai Institute of Diabetology and Endocrinology, Baqai Medical University Karachi. Period: March 2019 to May 2019. Material & Methods: After approval by the ethics committee of BMU. A world Health Organization (WHO) criterion was used for screening normal glucose tolerance. Subject with type 1 and 2 diabetes, and gestational diabetes were excluded. Selected subjects were categorized into 2 groups (anemic and non-anemic). Data was collected on a structured questionnaire. Result: Out of 139 subjects, 72 were males and 67, were females. Anemia was more common in males as compared to females (34.7% vs 19.4%). Among males, HbA1c level was found higher in anemic subjects with MCV<76fl than anemic subjects with MCV>76fl and subjects without anemia. While in females, HbA1c level was similar in both anemic and non-anemic subjects. Conclusion: HbA1c as a diagnostic marker should be assessed carefully as the presence of IDA can lead to falsely elevated HbA1c levels in non-diabetic subjects.

Author Biographies

Muhammad Saeed, Baqai Medical University Karachi.

M.Phil Student Biochemistry

Iftikhar Ahmed Siddiqui, Baqai Medical University Karachi.

Ph.D

Professor & Chairman Biochemistry 

Asher Fawwad, Baqai Medical University Karachi.

Ph.D

Professor & Head Biochemistry 

Anum Butt, Baqai Institute of Diabetology and Endocrinology Karachi.

M.Phil

Research Officer

Kahkashan Perveen, Baqai Medical University Karachi.

Ph.D

Assistant Professor Biochemistry

Ruqaya Nangrejo, Baqai Medical University Karachi.

M.Phil, Ph.D

Assistant Professor Physiology

Abdul Basit, Baqai Institute of Diabetology and Endocrinology Karachi.

FRCP

Professor Medicine

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Published

2021-08-10