Comparison of Salbutamol and Salbutamol with ipratropium bromide in children with exacerbation of Asthma in terms of peak expiratory flow rate (PEFR).

Authors

  • Sadaf Minhas Medicsi Hospital, Islamabad.
  • Saqib Aslam Emergency Mayo Hospital Lahore.
  • Muhammad Azhar Farooq Services Institute of Medical Sciences (SIMS), Lahore.
  • Ayesha Anwar Mayo Hospital Lahore.
  • Farhan Zahoor Services Institute of Medical Sciences (SIMS), Lahore.
  • Tehmina Maqbool Mayo Hospital Lahore.
  • Muhammad Ahsan Government General Hospital, Faisalabad.

DOI:

https://doi.org/10.29309/TPMJ/2021.28.11.5904

Keywords:

Children, Exacerbation of Asthma, Ipratropium Bromide Supplemented Salbutamol, PEFR, Salbutamol Alone

Abstract

Objective: To compare the Salbutamol alone and Ipratropium Bromide supplemented Salbutamol in children with exacerbation of asthma in terms of PEFR. Study Design: Randomized Controlled Trial. Setting: Pediatrics Emergency, KRL Hospital Islamabad. Period: 1st August 2016 to 31 January 2017. Material & Methods: Group A patients were given only Salbutamol (0.15mg/kg per dose with minimum 2.5 mg, maximum 5 mg/dose). Group B was given Ipratropium Bromide supplemented Salbutamol (250 mcg/dose for <20 kg while 500 mcg/dose for >20kg of Ipratropium Bromide with same dose of Salbutamol as prescribed for Group A). Baseline spirometry was performed on each patient and after measurement of baseline peak expiratory flow. The outcome was measured by Peak flow meter and reassessed at 60 minutes. Results: Comparison of salbutamol alone and ipratropium bromide supplemented salbutamol in children with exacerbation of asthma in terms of PEFR shows that 40.5 + 4.28 in Group-A and 59.5 +4.75 in Group-B, P-value was calculated as 0.0001, showing a significant difference between the two groups while the difference in increase was recorded as 19%. Conclusion: We concluded that salbutamol alone is significantly less effective when compared with Ipratropium Bromide supplemented Salbutamol in children with exacerbation of asthma in terms of PEFR.

Author Biographies

Sadaf Minhas, Medicsi Hospital, Islamabad.

MBBS, FCPS (Paediatric)

Senior Registrar Pediatrics

 

Saqib Aslam, Emergency Mayo Hospital Lahore.

MBBS, FCPS (Paediatric)

Senior Registrar Paeds

 

Muhammad Azhar Farooq, Services Institute of Medical Sciences (SIMS), Lahore.

MBBS, DCH, MRCPCH, FCPS

Assistant Professor Pediatric Medicine

Ayesha Anwar, Mayo Hospital Lahore.

MBBS, FCPS (Paediatric)

Assistant Professor Paeds Emergency Medicine

 

Farhan Zahoor, Services Institute of Medical Sciences (SIMS), Lahore.

MBBS, FCPS

Assistant Professor Pediatric Medicine

Tehmina Maqbool, Mayo Hospital Lahore.

MBBS, FCPS (Paediatric)

Assistant Professor Paeds Emergency Medicine

 

Muhammad Ahsan, Government General Hospital, Faisalabad.

MBBS, PGPN (Boston, USA)

Medical Officer Pediatrics

 

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Published

2021-10-31