A prospective randomized study to see the effects of combined administration of dexmedetomidine plus propofol versus propofol alone in cardiac surgical patients.

  • Sajid Farooq Bahawal Victoria Hospital, Bahawalpur, Pakistan.
  • Muhammad Farhan Ali Rizvi Bahawal Victoria Hospital, Bahawalpur, Pakistan.
  • Sana Urooj Hashmi Bahawal Victoria Hospital, Bahawalpur.
  • Mirza Ahmad Raza Baig Hail Cardiac Center, Hail, Saudi Arabia.
  • Hafiz Syed Muhammad Irfan Yousaf Bahawal Victoria Hospital, Bahawalpur, Pakistan.
  • Tasadduq Munir Bahawal Victoria Hospital, Bahawalpur, Pakistan.
Keywords: Cardiac Surgery, Dexmedetomidine, Propofol, Hemodynamics

Abstract

Objective: To compare the hemodynamics changes, intraoperative awareness and postoperative delirium after combined administration of dexmedetomidine plus propofol versus propofol alone in cardiac surgical patients. Study Design: Randomized Clinical Trial. Setting: Cardiac Center, Bahawal Victoria Hospital, Bahawalpur. Period: 1st December 2018 to January 2020. Material & Methods: Sixty-two (62) patients who underwent different cardiac surgical procedures were included in the study. Patients were randomly divided in group 1 {Dexmedetomidine (DEX) +Propofol} and group 2 {propofol alone}. Induction in group 1 was done by loading dose of DEX (0.7 microgram/kg) while induction in group 2 was done by Lignocaine 1.5 mg/kg. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and mean arterial pressure (MAP) were recorded at different time intervals. Intraoperative awareness and post-operative delirium was also assessed. Results: All hemodynamic parameters (HR, SAP, DAP, MAP) were statistically significant lower in group 1 in comparison to group 2 at different intervals indicating a more stable hemodynamic profile in group 1. End tidal CO2, pH, and peak airway pressures were not statistically significant between both groups. Intra-operative awareness was diagnosed in 1 (3.2%) patients in group 1 and in 5 (16.1%) patients in group 2 (p-value 0.08). Delirium was diagnosed in 3 (9.6%) patients in group 1 and in only 1 (3.2%) patients in group 2 (p-value 0.30). Conclusion: Combined administration of DEX and propofol produces more stable hemodynamics, less intraoperative awareness but more incidence of delirium as compared to propofol alone in cardiac surgical patients.

Author Biographies

Sajid Farooq, Bahawal Victoria Hospital, Bahawalpur, Pakistan.

MBBS, FCPS

Assistant Professor Anesthesia/ICU. Cardiac Center

Muhammad Farhan Ali Rizvi, Bahawal Victoria Hospital, Bahawalpur, Pakistan.

MBBS, FCPS

Assistant Professor Cardiac Surgery. Cardiac Center

Sana Urooj Hashmi, Bahawal Victoria Hospital, Bahawalpur.

MBBS

House Officer

Mirza Ahmad Raza Baig, Hail Cardiac Center, Hail, Saudi Arabia.

B.Sc. Hons. Cardiac Perfusion Technology)

Clinical Perfusion Specialist,

Hafiz Syed Muhammad Irfan Yousaf, Bahawal Victoria Hospital, Bahawalpur, Pakistan.

MBBS

Post Graduate Trainee Resident Cardiac Center

Tasadduq Munir, Bahawal Victoria Hospital, Bahawalpur, Pakistan.

FCPS

Anesthesia/ICU. Cardiac Center

Published
2021-04-10