Cold antibodies association with cellulitis, deep vein thrombosis and abnormal red cells indices: A Case Report.

Authors

  • Faiz Ahmed Faiz Islam Medical College, Sialkot.
  • Muhammad Faisal Bashir Khawaja Muhammad Safdar Medical College, Sialkot.
  • Sidra Ghazanfer Khawaja Muhammad Safdar Medical College, Sialkot.
  • Muhammad Fahad Faiz Shaukat Khanam Hospital, Lahore.
  • Muhammad Tayyab Sialkot Medcial College, Sialkot.
  • Khalid Aftab Sialkot Medical College, Sialkot.
  • Muhammad Tahir LGH, Lahore.
  • Imran Idrees Sialkot Medical College, Sialkot.

DOI:

https://doi.org/10.29309/TPMJ/2020.27.12.5513

Keywords:

Deep Vein Thrombosis (DVT), Ethylenediamine Tetra-acetic Acid (EDTA), Full Blood Count (FBC), Hemoglobin

Abstract

Objectives: To provide awareness to the pathologists and technologists all about the red cells parameters in cold antibodies concerned cases. Case Report Findings: A sixty seven-years-old male admitted in emergency department of our hospital, having clinical history of swelling and pain in both the lower limb and feet, on physical examination, provisionally diagnosed as a case of Cellulitis and deep vein thrombosis(DVT). Blood specimen was obtained for general hematological investigations. Full blood count (FBC) was performed on sysmex XP-100 hematological analyzer which showed invalid findings especially red cells indices which were not corresponding to the hemoglobin (Hb) concentration of the patient. Blood sample was repeated, to confirm invalid red cells indices which showed values as in the 1st blood specimen. Blood smears revealed aggregation of red cells. By warming the ethylenediamine tetra-acetic acid (EDTA) tube containing the blood specimen, in water bath at 37⁰C for one hour and repeated the FBC on hematological analyzer and found the corrected red cells indices. Conclusion: Basic knowledge of cold antibodies and warming the blood sample at 37⁰c for one hour helps the correct diagnosis.

Author Biographies

Faiz Ahmed Faiz, Islam Medical College, Sialkot.

MBBS, DCP, M.Phil (Haematology)

Assistant Professor Pathology

Muhammad Faisal Bashir, Khawaja Muhammad Safdar Medical College, Sialkot.

MBBS, FCPS (Haematology)

Assistant Professor Pathology

Sidra Ghazanfer, Khawaja Muhammad Safdar Medical College, Sialkot.

MBBS, FCPS (Hem), M.Phil (Histopathology)

Assistant Professor Pathology

Muhammad Fahad Faiz, Shaukat Khanam Hospital, Lahore.

MBBS

Resident Histopathology

Muhammad Tayyab, Sialkot Medcial College, Sialkot.

MBBS, M.Phil (Histopathology)

Professor Pathology

Khalid Aftab, Sialkot Medical College, Sialkot.

Ph.D (Pharmacological Sciences)

Professor Pharmacology

Muhammad Tahir, LGH, Lahore.

MBBS, DA

Consultant Anesthetist

 

Imran Idrees, Sialkot Medical College, Sialkot.

MBBS, FCPS (Surgery

Associate Professor

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Published

2020-12-10