SODIUM TUNGSTATE

EFFECT OF SODIUM TUNGSTATE ON KIDNEY OF STREPTOZOTOCIN INDUCED DIABETIC RABBIT.

  • Afra Samad Multan Medical and Dental College Multan.
  • Munawar Hussain Shah Nishtar Medical University Multan.
  • Rana Khalid Mahmood Nishtar Medical University Multan.
  • Muhammad Abubakre Khalid Shaikh Zayed Medical College Rahim Yar Khan.
  • Muhammad Usama Shaikh Zayed Medical College Rahim Yar Khan.
  • Muhammad Sulaiman Saeed Nishtar Medical University Multan.
Keywords: Sodium Tungstate (ST), Diabetes Mellitus, Streptozotocin (STZ)

Abstract

Objectives: The purpose of this study was to reveal the effects of sodium
tungstate (ST) on kidneys of diabetic rabbits. Study Design: Rabbits of 30 weeks age were
taken and divided into three groups A, B and C. Each group contained 10 animals. Group A was
selected as control group. Diabetes was induced in groups B and C by injecting streptozotocin
(50mg/mL) intraperitoneally. Group C was treated with sodium tungstate orally and group B was
left untreated. Histology of the kidney was examined in all of these groups using Hematoxylin
& Eosin (H & E), Reticulin and Trichrome stains. Blood glucose estimations of all animals
were performed every third day. Blood glucose levels of diabetic rabbits treated with sodium
tungstate were checked before and after treatment. Results were statistically analyzed using
students t-test. Place of Work: Post graduate medical institute Lahore. Duration of study:
July 2010 to August 2011. Results: Treatment of diabetic rabbits with sodium tungstate (Group
C) lead to lowering of blood glucose levels as compared to untreated diabetic rabbits (Group
B). Microscopic features of kidneys in groups B and C did not reveal any pathological and
morphological changes in comparison with control group A. Conclusion: Sodium tungstate is
a good anti-diabetic agent when administered orally and causes no morphological changes in
kidneys.

Author Biographies

Afra Samad, Multan Medical and Dental College Multan.

MBBS, DCP, M.Phil.
Assistant Professor,
Department of Pathology

Munawar Hussain Shah, Nishtar Medical University Multan.

MBBS, M.Phil.
Associate Professor,
Department of Pathology

Rana Khalid Mahmood, Nishtar Medical University Multan.

MBBS, M.Phil.
Assistant Professor,
Department of Pathology

Muhammad Abubakre Khalid, Shaikh Zayed Medical College Rahim Yar Khan.

MBBS
House Officer

Muhammad Usama, Shaikh Zayed Medical College Rahim Yar Khan.

MBBS
4th Year Student

Muhammad Sulaiman Saeed, Nishtar Medical University Multan.

B.Sc MLT, M.Sc. Biochemistry,
M.Phil. Biochemistry
Biochemist,
Department of Pathology

Published
2018-01-10