SODIUM TUNGSTATE
EFFECT OF SODIUM TUNGSTATE ON KIDNEY OF STREPTOZOTOCIN INDUCED DIABETIC RABBIT.
DOI:
https://doi.org/10.29309/TPMJ/2018.25.01.544Keywords:
Sodium Tungstate (ST), Diabetes Mellitus, Streptozotocin (STZ)Abstract
Objectives: The purpose of this study was to reveal the effects of sodium
tungstate (ST) on kidneys of diabetic rabbits. Study Design: Rabbits of 30 weeks age were
taken and divided into three groups A, B and C. Each group contained 10 animals. Group A was
selected as control group. Diabetes was induced in groups B and C by injecting streptozotocin
(50mg/mL) intraperitoneally. Group C was treated with sodium tungstate orally and group B was
left untreated. Histology of the kidney was examined in all of these groups using Hematoxylin
& Eosin (H & E), Reticulin and Trichrome stains. Blood glucose estimations of all animals
were performed every third day. Blood glucose levels of diabetic rabbits treated with sodium
tungstate were checked before and after treatment. Results were statistically analyzed using
students t-test. Place of Work: Post graduate medical institute Lahore. Duration of study:
July 2010 to August 2011. Results: Treatment of diabetic rabbits with sodium tungstate (Group
C) lead to lowering of blood glucose levels as compared to untreated diabetic rabbits (Group
B). Microscopic features of kidneys in groups B and C did not reveal any pathological and
morphological changes in comparison with control group A. Conclusion: Sodium tungstate is
a good anti-diabetic agent when administered orally and causes no morphological changes in
kidneys.
