CIRRHOSIS

HISTOLOGICAL CHANGES IN GASTRIC MUCOSA OF LIVER CIRRHOSIS PATIENTS.

Abstract

Objectives: To investigate the histological changes in gastric mucosa of liver
cirrhosis patients. Study design: Cross sectional study. Place and Duration: Department of
Anatomy and Medicine, Gastroenterology unit, Isra University Hospital (June to December
2012). Subjects and Methods: 85 diagnosed cases of liver cirrhosis were selected according
to inclusion and exclusion criteria. Specimen of 2 mm thickness was taken by punch biopsy
from gastric body and antrum by endoscope. Tissues were fixed in 10% formaldehyde, 3-5 μ
sections were stained with H & E for microscopy. Data was analyzed on SPSS version 21.0.
Results: Age (mean ±SD) was noted as 47±11.5 years. Of 85, 56 (65.8%) were male and
29 (34.1%) female. Frequency of mild, moderate, severe and no gastropathy were noted
in 52.94%, 34.12%, 4.71%, and 8.24% respectively. 9.4% of cases show capillary dilation
and edematous lamina propria. Conclusion: Microscopy shows gastropathy in majority of
specimens. Thick gastric mucosa, increased gland size and mucosa capillary dilation was
noted.