CIRRHOSIS

HISTOLOGICAL CHANGES IN GASTRIC MUCOSA OF LIVER CIRRHOSIS PATIENTS.

  • Afroz S Kazi Isra University
  • Aftab Abbasi Isra University
  • Sana Naz Suleman Roshan Medical College Tando Adam
Keywords: Liver Cirrhosis, Portal Gastropathy, Histology, Isra University

Abstract

Objectives: To investigate the histological changes in gastric mucosa of liver
cirrhosis patients. Study design: Cross sectional study. Place and Duration: Department of
Anatomy and Medicine, Gastroenterology unit, Isra University Hospital (June to December
2012). Subjects and Methods: 85 diagnosed cases of liver cirrhosis were selected according
to inclusion and exclusion criteria. Specimen of 2 mm thickness was taken by punch biopsy
from gastric body and antrum by endoscope. Tissues were fixed in 10% formaldehyde, 3-5 μ
sections were stained with H & E for microscopy. Data was analyzed on SPSS version 21.0.
Results: Age (mean ±SD) was noted as 47±11.5 years. Of 85, 56 (65.8%) were male and
29 (34.1%) female. Frequency of mild, moderate, severe and no gastropathy were noted
in 52.94%, 34.12%, 4.71%, and 8.24% respectively. 9.4% of cases show capillary dilation
and edematous lamina propria. Conclusion: Microscopy shows gastropathy in majority of
specimens. Thick gastric mucosa, increased gland size and mucosa capillary dilation was
noted.

Author Biographies

Afroz S Kazi, Isra University

MBBS, M.Phil
Professor
Department of Anatomy

Aftab Abbasi, Isra University

MBBS, M.Phil
Assistant Professor
Department of Anatomy

Sana Naz, Suleman Roshan Medical College Tando Adam

MBBS, M.Phil
Associate Professor
Department of Anatomy

Published
2018-01-10