Evaluation of endocrine and cardiac complications in survivors of childhood acute lymphoblastic leukemia: A single center study from south Punjab.

  • Waqas Imran Khan The Children Hospital & The Institute of Child Health, Multan.
  • Zulfiqar Ali The Children Hospital & The Institute of Child Health, Multan.
  • Sohail Arshad The Children Hospital & The Institute of Child Health, Multan.
Keywords: Acute Lymphoblastic Leukemia, Childhood, Cardiac, Endocrine, Late Complications

Abstract

Objectives: The objective of our study was to evaluate the endocrine and cardiac complications in survivors of childhood ALL. Study Design: Descriptive Cross Sectional study. Setting: Department of Pediatric Hematology-oncology, Endocrinology and Cardiology at The Children Hospital & Institute of Child health Multan (CH& ICH). Period: January 2019 to June 2019. Material & Methods: Sixty patients were enrolled after taking informed consent from patient/parents. Endocrine complications include (growth failure, overweight/obesity, hyperlipidemia, thyroid disorders, precocious puberty) and cardiac complications include hypertension and low ejection fraction were evaluated. Results: Out of 60 ALL survivors 32 were males (53.3%) and 28 were females (46.7%). At diagnosis patient’s age range was 7-17 years with median age of 11.6 years. At study median age was 17 years with age range of 13 to 23 years. Among our ALL survivors 56.6% had one complication and 25% had multiple problems. Obesity (25%), overweight (20%) and hyperlipidemia (26.4%) were the three common complications followed by short stature (5%), thyroid disorders (3.3%) and hypertension (3.3%). Conclusion: We report high prevalence (56.6%) of these complications from south Punjab. Therefore extended follow up of ALL survivors is needed in order to identify an abnormality and timely treatment and improved quality of life. 

Author Biographies

Waqas Imran Khan, The Children Hospital & The Institute of Child Health, Multan.

MBBS, DCH, FCPS (Paediatrics)

Associate Professor Paediatric Endocrinology

Zulfiqar Ali, The Children Hospital & The Institute of Child Health, Multan.

MBBS, DCH, FCPS (Paediatrics)

Assistant Professor Paediatric Hematology-oncology

Sohail Arshad, The Children Hospital & The Institute of Child Health, Multan.

MBBS, DCH, FCPS (Paediatrics), FCPS (Paediatric Cardiology)

Associate Professor Paediatric Cardiology

Published
2021-01-10