Correlation of VIT D3 and serum ferritin levels in anemic patients in a hospital based study.
Objectives: To determine the correlation of Vit D3 levels with serum ferritin in patients with anemia. Study Design: Cross Sectional study. Setting: Department of Pathology, Qazi Hussain Ahmed Medical Complex Nowshera. Period: 5th Jan 2019 to 31st Dec 2020. Material & Methods: Data entered in SPSS 25th version. Descriptive statistics was used for numerical variables. Pearson correlation was used for correlation of Vit D3 with gender. Normality of data was checked by Shapiro wilk test. Mann Whitney U test was used to show the difference of Vit D3 and ferritin levels in gender. Results: The total of 192 anemic patients with Hb<10g/dl as per definition of WHO1 were referred for ferritin level estimation with 142(74%) females and 50(26%) males. Out of total, 47 were also advised with Vit D3 level estimation with 29(61.7%) females and 18(38.3%) males. Mean with standard deviation for age was 30+9.6 years. Mean with standard Error of mean of Vit D3 was (Mean-15.5ng/ml, SE 2.19). Mean with standard Error of mean of serum ferritin was (Mean-48.2ng/ml, SE 5.90). We observed 35(74.5%) cases out of 47, as Vit D3 deficient with a count less than 20 ng/ml. We observed that 118 (61.5%) were iron deficient with serum ferritin less than 15ng/ml. Person correlation showed a statistically significant correlation of Vit D3 with ferritin (p= 0.022, r=0.7). Spearman ranked correlation showed a statistically significant correlation between the categories of Vit D3 and ferritin (p=0.022, r=0.7). Mann Whitney U Test showed no significant difference in gender groups for botht the variables (p= 0.86 &p=0.33 respectively) thus retain the null hypotheses. Conclusion: The frequency of deficiency Vit D3<20ng/ml in anemic patients was 74% while that of ferritin<15ng/ml in anemic patients was 61.5%. There is a strong statistically significant correlation of Vit D3 with serum ferritin in anemic patients with Hb<11g/dl.