Comparison of magnesium sulphate as an adjuvant to lignocaine with lignocaine alone in intravenous regional anaesthesia for upper limb surgery in improving tourniquet pain.

  • Syed Mehmood Ali Shaikh Zayed Hospital, Lahore.
  • Sadaf Bokhari Shaikh Zayed Hospital, Lahore.
  • Hajra Shuja Jinnah Hospital, Lahore.
Keywords: Intravenous Regional Anesthesia, Lignocaine, Magnesium Sulfate, Postoperative Analgesia


Objectives: To compare mean time to the first analgesic requirement with the Magnesium sulfate with lignocaine and lignocaine alone under intravenous regional anaesthesia for upper limb surgery. Study Design: Randomized Controlled Trial. Setting: Operative Rooms of Shaikh Zayed Hospital, Lahore. Period: October 2, 2018 to April 2, 2019. Material & Methods: For the analysis, a total of 150 (75 subjects per group) were selected that fulfilled the inclusion criteria. Those subjects were allocated by the use of the tables to two separate anesthetic regimes. Lignocaine plus magnesium sulphate was given to experimental group (M) as an adjunct and control group (L) was given simple IVRA with lignocaine. Mean Atrial Pressure, Heart Rate, and SpO2 were tracked every 2 minutes after start of anesthesia before and after use of the tourniquet. All the patients will be counseled to report if they experience tourniquet pain. When patients complained of tourniquet pain it was assessed on VAS of l-10 and patient was given analgesia if pain >3 on VAS. The data were collected and analyzed in SPSS v25.0. The median time for analgesics was used in both groups for the analysis of the independent t-test. A p-value of 0.05 was estimated significant. Results: 150 patients were enrolled. Mean time to first analgesic requirement is greater with the Magnesium sulfate with lignocaine and lignocaine alone in patients undergoing upper limb surgery under intravenous regional anaesthesia 51.9±4.2 minutes vs. 32.1±4.4 minutes (p=0.000). Conclusion: The findings indicate that the tourniquet pain is reduced by adding magnesium sulphate as an adjuvant to lignocaine.

Author Biographies

Syed Mehmood Ali, Shaikh Zayed Hospital, Lahore.

Associate Professor Anesthesia

Sadaf Bokhari, Shaikh Zayed Hospital, Lahore.

Senior Registrar Anesthesia

Hajra Shuja, Jinnah Hospital, Lahore.


Senior Registrar Anesthesia