Efficacy of amoxicillin-clavulanic acid versus ceftriaxone in children hospitalized under 5 years of age with uncomplicated community acquired pneumonia.

  • Huriya Abid The Children’s Hospital and The Institute of Child Health, Lahore.
  • Wajiha Rizwan The Children Hospital and Institute of Child Health, Lahore.
  • Irfan Naeem The Children Hospital and Institute of Child Health, Lahore.
  • Aysha Mansoor Lodhi The Children Hospital and Institute of Child Health, Lahore.
  • Muhammad Nasir Rana The Children Hospital and Institute of Child Health, Lahore.
Keywords: Amoxicillin, Ceftriaxone, Community Acquired Pneumonia, Efficacy

Abstract

Objectives: Community acquired pneumonia (CAP) is considered to be the commonest reason for hospitalization among children. Pneumonia is the leading cause of mortality among children in Pakistan in children, causing 33% of all deaths in infants and 37% of all deaths in children 1 to 4 years. The aim of current study was to compare efficacy of amoxicillin-clavulanic acid versus ceftriaxone among children under 5 years of age, hospitalized having uncomplicated CAP. Study Design: Randomized Controlled trial (RCT). Setting: Department of Pediatric Medicine, The Children Hospital and Institute of Child Health, Lahore. Period: 01/01/2019 to 30/06/2019. Material & Methods: A total of 210 (105 in each group) children aged between 2 to 60 months, diagnosed having CAP were randomly allocated into either Group-A (received IV amoxicillin-clavulanic acid) or Group B (received IV ceftriaxone). Efficacy in terms of response of both treatment groups was noted after 5 days treatment. Results: Overall, mean age was noted as 14.68±15.7 months. Majority (n=131, 32.4%) were male and aged between 1 to 12 months (n=135, 64.3%). Mean duration of symptoms was noted as 3.60±1.69 days. Efficacy was significantly higher in children treated with ceftriaxone as compared to those treated with Amoxicillin/Clavulanic acid (96.2% vs. 76.2%; p<0.001). This difference was significant across all age, gender and duration of symptom groups (p<0.05). Conclusion: The efficacy was significantly higher in children treated with ceftriaxone as compared to Amoxicillin/Clavulanic acid.

Author Biographies

Huriya Abid, The Children’s Hospital and The Institute of Child Health, Lahore.

FCPS (Paediatrics Medicine)

Senior Registrar Paediatrics Medicine

Wajiha Rizwan, The Children Hospital and Institute of Child Health, Lahore.

FCPS (Paediatrics Medicine)

Assistant Professor Paediatrics Medicine 

Irfan Naeem, The Children Hospital and Institute of Child Health, Lahore.

FCPS (Paediatrics Medicine)

Senior Registrar Paediatrics Medicine

Aysha Mansoor Lodhi, The Children Hospital and Institute of Child Health, Lahore.

FCPS (Paediatrics Medicine)

Senior Registrar Paediatrics Medicine

Muhammad Nasir Rana, The Children Hospital and Institute of Child Health, Lahore.

FCPS (Paediatrics Medicine)

Associate Professor & Head Paediatrics Emergency (M4)

Published
2020-11-10