Retinoblastoma treatment outcomes in Pakistan.

  • Asma Mushtaq The Children’s Hospital & Institute of Child Health, Lahore.
  • Asad Aslam Khan KEMU/Mayo Hospital, Lahore.
  • Mohammad Ali Ayaz Sadiq KEMU/Mayo Hospital, Lahore
  • Seema Qayyum The Children’s Hospital & institute of Child Health, Lahore.
  • Muhammad Rizwan Khan Holy family Hospital, Rawalpindi.
  • Ahmed Raza The Children’s Hospital & institute of Child Health, Lahore.
Keywords: Chemotherapy, Laser, Retinoblastoma, Tumor, Treatment

Abstract

Retinoblastoma is most common intraocular malignancy of childhood all over the world including Pakistan. Recent advances in the treatment of disease has improved the survival rates worldwide. Objective: To compare regression of retinoblastoma lesion after monotherapy (chemotherapy) vs combined therapy (chemotherapy + local consolidative therapy). Study Design: Randomized Control trial. Setting: Department of Pediatric Ophthalmology at College of Ophthalmology and Allied Vision Sciences/ King Edward Medical University, Mayo Hospital Lahore, Pakistan. Period: January 2015 to June 2016. Material & Methods: 43 patients with retinoblastoma (group C & D) were included in the study. Chemotherapy was given to patients in group1 and chemotherapy followed by local consolidative therapy was given to patients in group2. The percentage of regression of baseline lesion was noted after 6 cycles of chemotherapy. Results: The mean regression of lesion in group 1 was 24.5% and in group2 was 59.9%, after six months of treatment. The value t-test was 36.02 with p value 0.00 (<0.05). Conclusion: The combined modality of chemotherapy and local consolidative therapy is more effective in causing regression of retinoblastoma lesion than chemotherapy.

Author Biographies

Asma Mushtaq, The Children’s Hospital & Institute of Child Health, Lahore.

FRCS, FCPS, FPO

Assistant Professor Peadiatric Ophthalmology

 

Asad Aslam Khan, KEMU/Mayo Hospital, Lahore.

MS, PhD

Professor Ophthalmology

Mohammad Ali Ayaz Sadiq, KEMU/Mayo Hospital, Lahore

FCPS, FAO

Associate Professor Ophthalmology

Seema Qayyum, The Children’s Hospital & institute of Child Health, Lahore.

FCPS

Professor Ophthalmology

Muhammad Rizwan Khan, Holy family Hospital, Rawalpindi.

FCPS

Senior Registrar Ophthalmology

Ahmed Raza, The Children’s Hospital & institute of Child Health, Lahore.

FCPS, MRCS

Senior Registrar Ophthalmology

Published
2020-11-10