Subclinical hypothyroidism (SCH) in first trimester of pregnancy.

  • Kashif Ali Khan DG Khan Medical College Dera Ghazi Khan.
  • Muhammad Saleem Akhter Nishtar Medical University Multan.
  • Kehkashan Fatima Teaching Hospital Dera Ghazi Khan.
  • Muhammad Waqar Saleem Bakhtawar Amin Medical and Dental College Multan.
Keywords: First Trimester, Pregnancy, Subclinical Hypothyroidism

Abstract

Objectives: The prime objective of this study was to evaluate and asses the prevalence and related complications of SCH in pregnant ladies in their 1st trimester of pregnancy in Pakistani population. Study Design: Cross Sectional study. Setting: Department of Medicine, Teaching Hospital, DG Khan, Pakistan. Period: 11th February 2017 to 29th December 2018. Material & Methods: We obtained informed consent from all patients. 457 pregnant ladies having last missed period till 12th week with age group between 18-45 years were included in this study. Samples were collected for T4 (Thyroxine), TSH (Thyroid Stimulating Hormone) and T3 (Triiodothyronine). Patients were followed for their entire pregnancy period.  Adverse events and complications were noted. Results: Out of 457 patients who were included in our study, 169 subjects had TSH levels well above 4.6- 10 mIU/L. 288 subjects were having TSH levels below 4 mIU/L. The overall prevalence of subclinical hypothyroidism (SCH) was found to be 37% in pregnant women during their first trimester of pregnancy. Pregnant women having subclinical hypothyroidism (SCH) were having higher risks of loss of pregnancy, placental abruption and neonatal death rates as compared to euthyroid pregnant women. Conclusion: Our study concludes that overall prevalence of subclinical hypothyroidism (SCH) in Pakistani pregnant women during their first trimester of pregnancy was found to be 37%. Pregnant women having subclinical hypothyroidisms (SCH) were having higher risks of loss of pregnancy, placental abruption and neonatal death rates as compared to euthyroid pregnant women. In the light of these findings we recommend routine screening for TSH, free T3 and free T4 during pregnancy especially during 1st trimester of pregnancy.

Author Biographies

Kashif Ali Khan, DG Khan Medical College Dera Ghazi Khan.

MBBS, MCPS, FCPS

Assistant Professor Medicine

Muhammad Saleem Akhter, Nishtar Medical University Multan.

MBBS, FCPS

Associate Professor Medicine

Kehkashan Fatima, Teaching Hospital Dera Ghazi Khan.

MBBS, FCPS

Consultant Physician

Muhammad Waqar Saleem, Bakhtawar Amin Medical and Dental College Multan.

MBBS

Final Year Student

Published
2020-11-10