Effect of topical tacrolimus ointment on SCORAD index in pediatric atopic dermatitis.

  • Shazia Bano PUMHS Nawab Shah.
  • Munazzah Meraj PUMHS Nawab Shah.
  • Rao Irfan PUMHS Nawab Shah.                   
Keywords: Atopic Dermatitis, Excoriation, Erythema, Topical, Tacrolimus SCORAD

Abstract

Objectives: To determine topical tacrolimus ointment’s efficacy in atopic dermatitis. Study Design: Descriptive case series study. Setting: Outpatient Department of Dermatology, Liaquat University of Medical and Health Sciences (LUMHS), Civil Hospital, Hyderabad. Period: 12 October 2017 to 12 April 2018. Material & Methods: Consisted of 106 patients. Detailed History was taken from patients and systemic review was also done to assessed any co-morbidity. Data was analyzed through SPSS version 23.0. Results: In this study 71 (66.98%) patients were men and 35 (33.01%) were female; with male to female ratio 2:1. The mean age was 6.1+1.8 years. Clinical signs of patients were erythema 88(83.01%), edema 76(71.69%), Oozing/ crusting 45(42.45%), excoriation 59(55.66%) and lichenification 64(60.37%). Before treatment start the SCORAD index (SCORAD I) mean was 61.8 ± 11.12 (range 7–103): moderate cases were observed in 87(82.07%) patients (SCORAD I 30 – 49) and 19(17.92%) patients had severe AD (SCORAD I ≥50). After treatment, the SCORAD index mean was 35.8 ± 13.15 (range 7–103): 57(53.77%) patients had SCORAD index values ≤30; moderate cases (SCORAD I 30-49) were observed in 42(39.62%) patients and 7(6.60%) patients had severe AD (SCORAD I >50). In 57(53.77%) cases topical tacrolimus ointment (0.1%) showed positive efficacy in atopic dermatitis, while in 49(46.22%) cases observed negative. Conclusion: The application of topical tacrolimus ointment (0.1%) is effective in the treatment of atopic dermatitis in children.

Author Biographies

Shazia Bano, PUMHS Nawab Shah.

FCPS (Dermatology)

Assistant Professor

Munazzah Meraj, PUMHS Nawab Shah.

Ph.D Biochemistry

Associate Professor

 

Rao Irfan, PUMHS Nawab Shah.                   

Ph.D (Pharmaceutical Sciences)

Associate Professor

Published
2020-11-10