Comparative study of Glyceryl Trinitrate ointment versus lateral internal sphincterotomy in management of Chronic anal fissure.

  • Waqas Hussain Qureshi DHQ Teaching Hospital, Sahiwal.
  • Zahid Sattar Sahiwal Medical College, Sahiwal.
  • Akhtar Mahboob Sahiwal Medical College, Sahiwal.
  • Aakif Yousaf Sahiwal Medical College, Sahiwal.
  • Sajid Mukhtar Sahiwal Medical College, Sahiwal.
  • Waleeja Shamikha DHQ Teaching Hospital, Sahiwal.
Keywords: Chronic Anal Fissure, Glyceryl Trinitrate, Lateral Internal Sphincterotomy, Pain Relief

Abstract

Objectives: To compare efficacy of topical 0.2% glyceryl trinitrate ointment with lateral internal sphincterotomy in treatment of patients with chronic anal fissure. Study Design: Randomized Control Trial. Setting: Department of General Surgery, DHQ Teaching Hospital, Sahiwal. Period: From 20 September 2016 to 31 December 2017. Material & Methods: A total number of 60 patients included in this study and divided into two groups GTN and LIS group through computer generated randomization method. Three main outcome variables were assessed in this study; pain relief, healing of fissure and recurrence. SPSS version was used to analyze data. P value ≤ 0.05 was considered as significant. Results: A total number of 60 patients included in this study. Relief of pain GTN and LIS was (95%) and (86.7%) respectively. Fissure healing GTN and LIS was noted as (88.3%) and (83.3%) respectively. Recurrence was not found in any patient of the present study. Relief of pain was statistically significant. Conclusion: Topical application of GTN ointment for relief of pain is safe and effective method for relief of chronic anal fissure but pain relief is slow. On other hand lateral internal sphincterotomy is first line treatment and treatment of choice for chronic anal fissure when performed by an experienced surgeon.

Author Biographies

Waqas Hussain Qureshi, DHQ Teaching Hospital, Sahiwal.

MBBS, FCPS

Senior Registrar

Department of General Surgery

 

Zahid Sattar, Sahiwal Medical College, Sahiwal.

MBBS, FCPS

Associate Professor

Department of General Surgery

 

Akhtar Mahboob, Sahiwal Medical College, Sahiwal.

MBBS, FCPS

Associate Professor

Department of General Surgery

 

Aakif Yousaf, Sahiwal Medical College, Sahiwal.

MBBS, MRCS, FCPS

Assistant Professor

Department of General Surgery

 

Sajid Mukhtar, Sahiwal Medical College, Sahiwal.

MBBS, FCPS

Assistant Professor

Department of General Surgery

 

Waleeja Shamikha, DHQ Teaching Hospital, Sahiwal.

MBBS, FCPS

Senior Registrar

Department of General Surgery

 

Published
2019-12-10