Phototherapy in full term neonates suffering from unconjugated hyperbilirubinemia; Does it affect platelet count?

  • Adnan Bashir Hamdard College of Medicine and Dentistry Hamdard University Hospital, Karachi.
  • Ashok Kumar Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi.
  • Nathumal Maheshwari Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi.
  • Bilawal Hingorjo Dow University of Health Sciences/ Civil Hospital Karachi.
  • Shakeel Ahmed National Institute of Child Health Karachi.
  • Saher Fatima Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi.
Keywords: Neonatal Hyperbilirubinemia, Phototherapy, Platelet Count

Abstract

Objectives: Investigating the hazardous effect of Phototherapy on Platelet counts in healthy neonates with Neonatal hyperbilirubinemia (NH). Study Design: Cross Sectional study. Setting: Department of Paediatrics, SMBB Medical College Layari General Hospital, Karachi, Sindh. Period: January 2018 to May 2019. Material & Methods: A sample of 313 neonates suffering from NH was selected according to the inclusion and exclusion criteria. Blood Platelets were counted at baseline, and 24, 48 and 72 hours of phototherapy. Statistical software SPSS 21.0 (IBM, Incorp, USA) was used for data analysis using paired t-test and Pearson`s Chi- square test at P≤0.05. Results: Platelet counts at 24, 48 and 72 hours of phototherapy were found 2.97±0.45×109/L, 3.38±0.48×109/L and 3.52± 0.47×109/L respectively. Platelet counts at 24, 48 and 72 hours showed statistically significant difference compared to baseline counts (P<0.05). A statistically insignificant decline in total population platelet count after phototherapy was noted (P>0.05). However, thrombocytopenia was noted in 9 (2.87%) cases; comprising mild and moderate in 7 (2.23%) and 2 (0.64%) cases respectively. Conclusion: The present study observed thrombocytopenia in 9 (2.87%) of total cases; of which mild and moderate thrombocytopenia occurred in 7 (2.23%) and 2 (0.64%) cases respectively.

Author Biographies

Adnan Bashir, Hamdard College of Medicine and Dentistry Hamdard University Hospital, Karachi.

MBBS, FCPS

Assistant Professor Paediatrics

Ashok Kumar, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi.

MBBS, FCPS

Senior Registrar Paediatrics

Nathumal Maheshwari, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi.

MBBS, MCPS, FCPS

Assistant Professor Paediatrics

Bilawal Hingorjo, Dow University of Health Sciences/ Civil Hospital Karachi.

MBBS, FCPS

Assistant Professor Pediatrics

Shakeel Ahmed, National Institute of Child Health Karachi.

MBBS, FCPS

Senior Registrar Pediatrics

Saher Fatima, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi.

MBBS, FCPS

Associate Professor Gyne & Obs

Published
2020-09-10