Evaluating efficacy of oral zinc as adjuvant therapy in acute diarrhea in children.

  • Nathumal Maheshwari Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi.
  • Nadeem Noor Hamdard College of Medicine and Dentistry  Hamdard University Hospital, Karachi.
  • Adnan Bashir Hamdard College of Medicine and Dentistry  Hamdard University Hospital, Karachi.
  • Bilawal Hingorjo Dow University of Health Sciences/ Civil Hospital Karachi.
  • Arshad Ali Karachi Institute of Medical Sciences, Malir Cantonment, Karachi.
  • Urooj Tabassum Dow International Medical College, Dow University of Health Sciences.
Keywords: Acute Diarrhea, Duration, Frequency Stool, Zinc Supplement

Abstract

Objectives: To evaluate the efficacy of oral zinc as adjuvant therapy in acute diarrhea comparing frequency and volume of stool and duration of diarrhea in children. Study Design: Case Control study. Setting: Department of Paediatrics, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital, Karachi. Period: September 2017 to August 2018. Material & Methods: A sample of 200 children, age 5- 15 years, suffering from acute diarrhea was divided into control and cases (study group). Oral zinc therapy (20 mg once daily) was given 14 days and its efficacy was observed in terms of stool frequency, stool volume and duration of diarrhea. Variables were noted at 24 hours and 48 hours and on 7th day of hospitalization. Data was analyzed on SPSS statistical software (version 22.0) at 95% confidence interval (P≤ 0.05). Results: Mean ± SD age in control and study group was noted as 9.1± 5.43 years and 9.5±6.02 years respectively (P=0.053). 89% of children of study group were discharged on 3rd day of hospitalization compared to only 45% from control group.  Zinc treated study group shows significant decrease in frequency of loose stools, stool volume and lesser duration of hospital stay. Conclusion: Oral zinc therapy was effective in decreasing the frequency of loose stools and volume and lesser duration of hospital stay in children.

Author Biographies

Nathumal Maheshwari, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi.

MBBS, MCPS, FCPS

Assistant Professor Paediatrics

 

Nadeem Noor, Hamdard College of Medicine and Dentistry  Hamdard University Hospital, Karachi.

MBBS, DCH, FCPS, MRCPCH

Assistant Professor Pediatrics

Adnan Bashir, Hamdard College of Medicine and Dentistry  Hamdard University Hospital, Karachi.

MBBS, FCPS

Assistant Professor Paediatrics

Bilawal Hingorjo, Dow University of Health Sciences/ Civil Hospital Karachi.

MBBS, FCPS

Assistant Professor Pediatrics

Arshad Ali, Karachi Institute of Medical Sciences, Malir Cantonment, Karachi.

MBBS, MD

Associate Professor Medicine

Urooj Tabassum, Dow International Medical College, Dow University of Health Sciences.

MBBS, FCPS

Assistant Professor Psychiatry

Published
2020-08-10