Microalbuminuria and its association with glycemic control in patients with diabetes mellitus type II.

  • Shahzad Ali Jiskani Indus Medical College Tando Muhammad Khan.
  • Dolat Singh Indus Medical College Tando Muhammad Khan.
  • Kumayl Abbas Meghji Isra University Hyderabad.
  • Rizwan Ali Talpur Isra University Hyderabad.
  • Jahanzaib Khan Isra University Hyderabad.
  • Hina Nazeer Khanzada Isra University Hyderabad.
Keywords: Diabetes Mellitus, Diabetic Nephropathy, Glycemic Control, Hyperglycemia, Microalbuminuria

Abstract

Diabetes mellitus is chronic condition with defect in regulation of insulin. Microalbuminuria is one of the early appearing markers of overt diabetic nephropathy. Uncontrolled glycemic status has been postulated to be associated with increase urinary albumin levels. Objectives: To find out the association of increased urinary albumin with poor glyemic status of patients with diabetes mellitus type II. Study Design: Cross Sectional study. Setting: Department of Pathology, Indus Medical College Hospital Tando Muhammad Khan. Period: November 2018 to June 2019. Material & Methods: Patients were divided into two groups: Group I (Poor glycemic control, HbA1c >7%) and Group II (Good glycemic control, HbA1c <7%). Glycated hemoglobin and microalbuminuria were evaluated in all patients. Data was analyzed using SPSS 21.0. P – value of <0.05 was considered as statistically significant. Results: Total of 213 patients were included in the study with male ratio (56.8%) slightly higher than females (43.19%). Mean age of patients was 42.3 ± 2.1 years. Mean glycated hemoglobin in Group I and II was 8.12 ± 0.97% and 5.98 ± 0.41% respectively. In Group I, 57.54% patients were detected with microalbuminuria as compared to Group II (12.26%). P value was statistically significant (<0.001). Conclusion: Microalbuminuria was found more frequently in patients with poor glycemic control. Early detection of urinary microalbumin in these patients may decrease the risk of kidney damage and appropriate and adequate management in initial stage.

Author Biographies

Shahzad Ali Jiskani, Indus Medical College Tando Muhammad Khan.

MBBS, M.Phil (Haematology)

Assistant Professor Pathology

Dolat Singh, Indus Medical College Tando Muhammad Khan.

MBBS, MD (Medicine)

Assistant Professor Medicine

Kumayl Abbas Meghji, Isra University Hyderabad.

MBBS, M.Phil (Physiology)

Assistant Professor Physiology

Rizwan Ali Talpur, Isra University Hyderabad.

MBBS, M.Phil (Physiology)

Assistant Professor Physiology

Jahanzaib Khan, Isra University Hyderabad.

MBBS, M.Phil (Anatomy)

Assistant Professor Anatomy

Hina Nazeer Khanzada, Isra University Hyderabad.

MBBS, M.Phil (Biochemistry)

Assistant Professor Biochemistry

Published
2020-08-10