Hepatitis E associated fulminant hepatic failure and its outcome in pregnancy.

  • Zahida Parveen Brohi Bilawal Medical College for Boys (LUMHS). Jamshoro Sindh, Pakistan.
  • Uzma Parveen Isra University Hospital Hyderabad Sindh, Pakistan.
  • Aneela Sadaf Services Hospital Karachi Sindh, Pakistan.
Keywords: Fulminant Hepatic Failure, Mortality, Pregnancy

Abstract

Objectives: To determine the clinical features and outcome of hepatitis E associated fulminant hepatic failure in pregnancy. Study Design: Observational Retrospective study. Setting: Department of Obstetrics & Gynecology at Isra University Hospital Hyderabad. Period: Three years from 1st January 2015 to 31st December 2017. Material & Methods: Total 3596 obstetric patients were admitted whom 168 pregnant women who were positive for hepatitis E viral marker have been included in the study. Results: Their age was between 18 to 47 years with mean age 26.04±6.40 years; majority of patients had not received antenatal care 123 (73.2%). Out of 168, 27 (16%) presented in the first trimester, 45 (26.7%) presented in the second trimester, while 96 (57.1%) patients developed fulminant hepatic failure in their 3rd trimester of pregnancy. Out of 168, 111(66%) patients delivered and 57 (33.9%) were undelivered. Fetal and perinatal outcome of delivered patients showed miscarriage 45 (40.5%), stillborn 25(14.8%), preterm delivery 17(15.3%), neonatal death 7 (6.3%) and 17 (15.3%) new born remained alive. Overall maternal mortality was 51 (30.3%). Conclusion: Hepatitis – E related fulminant hepatic failure in pregnancy is a troublesome clinical issue and connected with exceptionally high maternal and fetal mortality. Appropriate diagnosis, early timely intervention can considerably diminish the morbidity and mortality associated with (HEV) Fulminant hepatic failure. 

Author Biographies

Zahida Parveen Brohi, Bilawal Medical College for Boys (LUMHS). Jamshoro Sindh, Pakistan.

MBBS, FCPS

Associate Professor Obstetrics & Gynecology

Uzma Parveen, Isra University Hospital Hyderabad Sindh, Pakistan.

MBBS, FCPS

Assistant Professor Obstetrics & Gynecology

 

Aneela Sadaf, Services Hospital Karachi Sindh, Pakistan.

MBBS, MS (Gynecologist) 

Gynecologist Obstetrics & Gynecology

 

Published
2020-10-10