Demographic features of pediatric B-ALL (B Lineage Acute Lymphoblastic Leukemia) patients in Pakistani population.

  • Moizza Sahar University of Health Sciences, Lahore.
  • Saira Gul University of Health Sciences, Lahore.
  • Farhana Shehzad Children Hospital and Institute of Child Health, Lahore.
  • Shahida Mohsin University of Health Sciences, Lahore.
Keywords: B-ALL, B Lineage Acute Lymphoblastic Leukemia, LDH: Lactate Dehydrogenase, TLC: Total Leucocyte Count

Abstract

Objectives: This study was conducted to evaluate demographic features of pediatric B-ALL patients in Pakistani population and their prognosis in a Tertiary Care Hospital. Study Design: Descriptive study. Setting: Department of Pathology Tertiary Care Children Hospital, Lahore. Period: 1st January 2016 to 31st December 2016. Material & Methods: A total of 66 samples of newly diagnosed B-ALL patients (aged 1-15 years) were taken for study. For diagnosis of B-ALL, bone marrow aspiration, cytochemical staining, immunophenotyping was done. Results: Out of 66 B-ALL patients, 35 (53%) were males and 31 (47%) were females. The median age for pediatric ALL subjects was 5 years. Out of 66 B-ALL patients, 39 (59%) were in standard risk group. The prognosis of ALL patients in our study was poor as compared with international statistics with 12/21 deaths (57%) in standard risk group. Also, history of consanguinity of parents was significantly high in dead patients (p = 0.013). Deaths were also comparatively more in males than in females. Conclusion: The prognosis of pediatric B-ALL patients in our study was poor as compared with international statistics because of multifactorial reasons. Strategies are needed to be adopted to improve the outcome of B-ALL patients in our population.

Author Biographies

Moizza Sahar, University of Health Sciences, Lahore.

MBBS, M.Phil (Hematology)

Senior Demonstrator Hematology

Saira Gul, University of Health Sciences, Lahore.

MBBS, M.Phil

Medical Officer Hematology

Farhana Shehzad, Children Hospital and Institute of Child Health, Lahore.

MBBS, FCPS

Assistant Professor Immunology

Shahida Mohsin, University of Health Sciences, Lahore.

MBBS, FCPS

HOD Hematology

Published
2020-08-10