Frequency of fungal infections in nasal polypi.

  • Uzma Aslam Shalamar Medical & Dental College, Lahore.
  • Nausheen Henna Niazi Medical & Dental College, Sargodha.
  • Aman-ur- Rehman Shaikh Zayed Hospital, Lahore.
  • Saniyah Ali Shalamar Medical & Dental College, Lahore.
  • Shireen Hamid Independent Medical College, Faisalabad.
  • Saroash Iqbal Frontier Medical College, Abbottabad.
Keywords: Aspergillus, Fungal Infection, Mucormycosis, Nasal Polyps

Abstract

Objectives: Determine the frequency of fungal infections in nasal polypi. Study Design: Cross sectional study. Setting: Histopathology Department at Shaikh Zayed Hospital Lahore. Period: Six months from 12/2/2015 to 12/8/2015. Material & Methods: Two hundred surgical resections/biopsies using 95% confidence level, with 7% margin of error were collected. Formalin fixed specimens of patients of both genders and 10- 60 years of age with nasal polyps received after surgical procedure in department of ENT. Grossing and processing was done. Hematoxyin & Eosin stained sections were examined by two consultant Histopathologists independently. The presence of fungal hyphae was confirmed by PAS and Silver stains. The study was approved by College of Physicians & Surgeons Pakistan. All the data was entered and analyzed by using SPSS version 20. Results: Out of 200 patients all the patients showed the prescence of inflammatory cells in polyps (100%) with predominantly eosinophils in their submucosa (82%). Fungus was present in 48 cases (24%) most of them were in the age group of 42-57 years (13%) and 31(15.5%) patients having BMI <30 and 17(8.5%) having BMI >30 were positive for fungus.30 cases were of Aspergillus (62.5%) and rest 8 were of Mucor (37.5%). The fungus positive cases were more in males (13.5%). 160 of the cases were of unilateral polyps (80%) and 40 were of bilateral polypi (20%). Only 8% of the patients having diabetes had fungal infection. Conclusion: Hence, the frequency of fungal infection in nasal polypi is low with Aspergillus being the commonest pathogen affecting males predominantly.

Author Biographies

Uzma Aslam, Shalamar Medical & Dental College, Lahore.

MBBS, FCPS

Senior Demonstrator

Department of Pathology

 

Nausheen Henna, Niazi Medical & Dental College, Sargodha.

MBBS, M.Phil, FCPS, DipRCPath

Associate Professor

Department of Pathology

 

Aman-ur- Rehman, Shaikh Zayed Hospital, Lahore.

MBBS, FCPS

Professor

Department of Pathology

 

Saniyah Ali, Shalamar Medical & Dental College, Lahore.

MBBS

Senior Demonstrator

Department of Pathology

 

Shireen Hamid, Independent Medical College, Faisalabad.

MBBS, FCPS

Senior Demonstrator

Department of Pathology

 

Saroash Iqbal, Frontier Medical College, Abbottabad.

MBBS, FCPS

Assistant Professor

Department of Pathology

 

Published
2019-12-10