Association of serum Vitamin D and omentin-1 in patients with coronary artery disease.

  • Shazia Nazar DIKIOHS, DUHS.
  • Ambreen Qamar DIKIOHS, DUHS.
  • Akbar Mughal Karchi Medical & Dental College, Karachi.
  • Fareeha Butt Dow Medical College, Karachi.
Keywords: Coronary Artery Disease, Omentin-1, Vitamin D

Abstract

Objectives: The aim of the present study was to investigate the association between serum vitamin D (calcediol, D2) with omentin-1 in patients with coronary artery disease (CAD). Study Design: Case Control Study/ Cross Sectional Study. Setting: Civil Hospital Karachi (CHK). Period: January 2016 to June 2016. Material & Methods: In this cross-sectional study, total of 250 cases of coronary artery disease were recruited randomly from the civil hospital, Karachi. Diagnosis based upon coronary angiography. Serum Vitamin D and omentin levels determined by using enzyme linked immunosorbent essay (ELISA) in Dr. Abdul Qadeer khan Institute of Biotechnology and Genetic Engineering (KIBGE). 120 apparently healthy controls were recruited. Results: we observed significant low levels of serum vitamin D and omentin-1in patients of coronary artery disease. Vitamin D (calcidiole, D2) deficiency (<30ng/L) was found in 82 % (n= 205) of CAD patients, moreover; 50.8% (n=127) patients were found with severe vitamin D deficiency (8.77± 3.87) placed in group III, 31.2% (n=78) patients were found with moderate deficiency (17.09 ±4 ng/mL) in group II, whereas only 18% (n=45) had optimal serum vitamin D levels (33.02 ±16.00 ng/ mL) placed in group I. Mean serum omentin-1 level was (578± 21.87, 409±32.09, 321± 23.01) in these subgroups respectively. Serum vitamin D (calcidiole, D2) level was associated positively with omentin-1 in CAD patients (P = 0.002) after adjustment for potential confounding variables; basal metabolic rate, waist circumference, blood pressure and lipid profile. Conclusion: Within the limits of the study, we concluded that low levels of vitamin D and omentin-1 are associated with prevalent coronary artery disease (CAD) and are independent of other cardiovascular risk factors. Further investigations are required in different ethnic groups and populations to confirm the findings.

Author Biographies

Shazia Nazar, DIKIOHS, DUHS.

MBBS, M.Phil

Assistant Professor Physiology

Ambreen Qamar, DIKIOHS, DUHS.

MBBS, M.Phil, Ph.D Fellow

Associate Professor Physiology

 

Akbar Mughal, Karchi Medical & Dental College, Karachi.

MBBS, M.Phil, Ph.D

Associate Professor Physiology

Fareeha Butt, Dow Medical College, Karachi.

MBBS, M.Phil

Assistant Professor Physiology

Published
2020-06-10