Frequency of elevated plasma homocysteine (Hcy) levels among type 2 Diabetes mellitus (T2DM) patients.

  • Tahreem Ansari Indus Hospital. Karachi.
  • Ajmaal Jami Hamdard University of Medicine and Dentistry.
  • Bushra Rabbani Baqai Medical University.
  • Ghazanfar - Indus Hospital. Karachi.
  • Mahnoor Khalil Abbasi Shaheed Hospital.
  • Qaiser Jamal Abbasi Shaheed Hospital.
Keywords: Frequency, Homocysteinemia, Stratification, Type 2 Diabetes


Objectives: To determine the frequency of elevated plasma homocysteine (Hcy) levels among type 2 diabetes mellitus (T2DM) patients. Study Design: Cross sectional study. Setting: Department of Medicine, Abbasi Shaheed Hospital, Karachi. Period: From 28 September 2012 to 26 March 2015. Material & Methods: Type 2 Diabetic patients fulfilling inclusion criteria were enrolled. Patients with conditions known to cause altered homocysteine levels were excluded. Patients’ HbA1c and fasting serum homocysteine levels were obtained. Level >15 μmol/L was labeled as elevated.  Data was collected with the help of Performa. Data was analyzed using SPSS version 21. Results: (90) ninety patients were enrolled in this study during study period with mean age of 61.5±7.3 years. Of (90) ninety patients, 45 (50%) were male and 45 (50%) were female with male to female ratio of 1:1. Mean duration of diabetes was 6.9±1.7 years. 40 (44.44%) cases were of controlled diabetes and 43 (47.7%) were on treatment. Of 90 patients 36 (40%) patients had Homocysteinemia. Homocysteine levels were found to be significantly raised in males 51.1% v/s 28.8% (p<0.03), older patients (>60 years of age) 55.5% v/s 16.6% (p<0.001), having diabetes for > 7 years, 59.2% v/s 17%(p<0.00004), in 21% v/s 57.4% cases who were and were not on treatment respectively (p<0.0004), in 22.5% patients with controlled diabetes and 54% patients with uncontrolled diabetes respectively (p<0.002). Conclusion: Hyperhomocystenemia is prevalent (40%) in type 2 diabetics with statistically significant raised levels in males, >60 years of age, non-compliant diabetics, have long duration diabetes, and uncontrolled disease.

Author Biographies

Tahreem Ansari, Indus Hospital. Karachi.

MBBS, FCPS (Medicine)

Associate Consultant Medicine

Ajmaal Jami, Hamdard University of Medicine and Dentistry.


Assistant Professor Medicine


Bushra Rabbani, Baqai Medical University.


Assistant Professor


Ghazanfar -, Indus Hospital. Karachi.


Associate Consultant Medicine


Mahnoor Khalil, Abbasi Shaheed Hospital.


Assistant Professor Medicine


Qaiser Jamal, Abbasi Shaheed Hospital.


Professor & Head Medicine