Impact of hyponatremia on outcome of acute ischemic stroke in a tertiary care hospital.

  • Aneela Altaf Kidwai Abbasi Shaheed Hospital, Karachi.
  • Jamal Ara Abbasi Shaheed Hospital, Karachi.
  • Shumaila Abdul Rasheed Abbasi Shaheed Hospital, Karachi.
  • Najeebullah - Abbasi Shaheed Hospital, Karachi.
  • Saleemullah Paracha Abbasi Shaheed Hospital, Karachi.
Keywords: Acute Ischemic Stroke, Hyponatremia and Mortality

Abstract

Objectives: To determine the frequency and impact of hyponatermia on outcome in patients of acute ischemic stroke admitted to a Tertiary Care Hospital, Karachi. Study Design: Prospective, cross-sectional, observational study. Setting: Department of Medicine, Abbasi Shaheed Hospital, Karachi. Period: January 2015 to May 2018. Material and Methods: A total of 110 patients of both gender presented with acute ischemic stroke and hyponatermia (2 consecutive serum sodium levels (< 135 mEq/L). Diagnosis of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and cerebral salt wasting (CSW) was based on predefined criteria. Mortality was considered in terms of modified Rankin Scale with score of 6 within four weeks of admission. Data was analyzed by using SPSS Version 20. Result: Out of 110 acute ischemic stroke patients, 66 (60%) were male and 44 (40%) were female. The mean age was 61.45 ± 11.8 years. Mean serum sodium level was 128.4 ± 6.07. Older ages are associated with high mortality rate of 20%. Moderate (29%) and severe (11%) hyponatremia was associated with 21% and 33% mortality respectively. Overall mortality in patients with hyponatremia was 14.5%. Conclusion: Mortality rates are higher in acute ischemic stroke patients presented with moderate to severe hyponatremia.

Author Biographies

Aneela Altaf Kidwai, Abbasi Shaheed Hospital, Karachi.

FCPS

Professor

Department of Medicine

 

Jamal Ara, Abbasi Shaheed Hospital, Karachi.

FCPS

Assistant Professor

Department of Medicine

 

Shumaila Abdul Rasheed, Abbasi Shaheed Hospital, Karachi.

MBBS

Post Graduate Trainee

Department of Medicine

 

Najeebullah -, Abbasi Shaheed Hospital, Karachi.

MBBS

Post Graduate Trainee

Department of Medicine

 

Saleemullah Paracha, Abbasi Shaheed Hospital, Karachi.

MRCP

Professor

Department of Medicine

 

Published
2019-10-10