Positive predictive value (PPV) of computed tomography in diagnosing wilms’ tumor using histopathology as gold standard.

  • Mumtaz Rasool Bahawal Victoria Hospital/ Quaid-e-Azam Medical College, Bahawalpur.
  • Mudassar Saeed Pansota Shahida Islam Medical College, Lodhran.
  • Fariha Mumtaz Bahawal Victoria Hospital/ Quaid-e-Azam Medical College, Bahawalpur.
  • Muhammad Shahzad Saleem Bahawal Victoria Hospital/ Quaid-e-Azam Medical College, Bahawalpur.
  • Shafqat Ali Tabassum Bahawal Victoria Hospital/ Quaid-e-Azam Medical College, Bahawalpur.
Keywords: Computed Tomography, False Positive, Histopathology, Imaging, Positive Predictive Value, True Positive, Wilm’s Tumour

Abstract

CT can also accurately identify vascular invasion that will impact surgical approach along with identification of the preoperative parameters associated with increased risk of intraoperative Wilms’ tumor spill. Objectives: To determine positive predictive value of CT scan in diagnosing wilm’s tumour, taking histopathology as gold standard. Study Design: Descriptive, cross sectional study. Setting: Department of Urology & Renal Transplantation Centre, Bahawal Vitoria Hospital, Bahawalpur. Period: From July 2017 to June 2018. Materials & Methods: A total of 81 patients with suspected wilm’s tumour on ultrasonography of age 1-12 years of either gender were included. Patients with recurrent tumour and undergoing pre-op chemotherapy were excluded. All the patients were then underwent CT scan and looked for presence or absence of wilm’s tumour. The results were compared with histopathology. Results: Mean age was 5.23 ± 3.28 years. Majority of the patients 56 (69.14%) were between 1 to 6 years of age. Out of these 81 patients, 61 (75.31%) were female and 20 (24.69%) were males with female to male ratio of 2.9:1. CT scan supported the diagnosis of wilm’s tumour in all 46 patients. Histopathology confirmed wilm’s tumour in 41 (true positive) cases where as 05 (False Positive) had no wilm’s tumour on histopathology. Positive predictive value of CT scan in diagnosing wilm’s tumour, taking histopathology as gold standard was 89.13%. Conclusion: This study concluded that positive predictive value of CT scan in diagnosing wilm’s tumour is quite high.

Author Biographies

Mumtaz Rasool, Bahawal Victoria Hospital/ Quaid-e-Azam Medical College, Bahawalpur.

FCPS

Associate Professor

Department of Urology and Renal Transplantation

 

Mudassar Saeed Pansota, Shahida Islam Medical College, Lodhran.

MS Urology

Assistant Professor

Department of Urology

 

Fariha Mumtaz, Bahawal Victoria Hospital/ Quaid-e-Azam Medical College, Bahawalpur.

FCPS

Senior Registrar

Department of Radiology

 

Muhammad Shahzad Saleem, Bahawal Victoria Hospital/ Quaid-e-Azam Medical College, Bahawalpur.

FCPS

Senior Registrar

Department of Urology and Renal Transplantation

 

Shafqat Ali Tabassum, Bahawal Victoria Hospital/ Quaid-e-Azam Medical College, Bahawalpur.

FCPS

Head

Department of Urology and Renal Transplantation

 

Published
2019-10-10