Histomorphological effect of celecoxib on cellular diameter of proximal convoluted tubules of kidney with protective effect of lycopene in albino rats; an experimental study.

  • Sadia Sundus Hamdard Medical University, Karachi.
  • Maria Mohiuddin Hamdard Medical University, Karachi.
  • Sarwath Fatimee Fatima Jinnah Dental College, Karachi.
  • Ashoke Kumar Shaheed Mohtarma Benazir Bhutto  Medical College, Karachi.
  • Shah Jabeen Liaquat College of Medicine & Dentistry, Karachi.
  • Sahar Mubeen Dow International Medical College, Karachi.
Keywords: Celecoxib, Infiltration, Lycopene

Abstract

Objectives: To observe the cellular diameter of proximal convoluted tubules of kidney of albino rats on celecoxib induced kidney with protection by lycopene. Study Design: Experimental study. Setting: BMSI (Anatomy Department), JPMC, Karachi. Period: 4th May 2015 to 3rd June 2015. Materials and Methods: Ninety to one twenty days old, forty healthy adult, male Albino rats of 200-220gm were taken for the study. The rats were divided into 4 groups, Group A was control group, Group B  receive Celecoxib  50 mg/kg body weight orally,  Group C receive Celecoxib 50 mg/kg body weight orally along with lycopene50 mg/kg body weight orally and Group D receive lycopene 50 mg/kg body weight orally for 30 days. At the end of study rats were sacrificed and renal tissue sections were stained with hematoxylin and eosin. Results: Markedly increased cellular diameter of proximal convoluted tubules was observed in rats taking celecoxib. Slides stained with hematoxylin and eosin showed altered and degenerative changes in the renal parenchyma of cortex and medulla. Ballooning of cells, hemorrhage and moderate edema was seen in celecoxib group. Renal interstitium showed infiltration of mononuclear cells, congested and dilated blood vessels. However, renal architecture was improved and reversed in celecoxib along with lycopene receiving group. Conclusion: This study concludes that lycopene decreased the cellular diameter of proximal convoluted tubules in celecoxib treated group.

Author Biographies

Sadia Sundus, Hamdard Medical University, Karachi.

MBBS, M.Phil

Assistant Professor

Department of Anatomy

Maria Mohiuddin, Hamdard Medical University, Karachi.

MBBS, M.Phil

Assistant Professor

Department of Anatomy

 

Sarwath Fatimee, Fatima Jinnah Dental College, Karachi.

MBBS, M.Phil

Associate Professor & HOD

Department of Anatomy

 

Ashoke Kumar, Shaheed Mohtarma Benazir Bhutto  Medical College, Karachi.

MBBS, M.Phil

Assistant Professor

Department of Anatomy

 

Shah Jabeen, Liaquat College of Medicine & Dentistry, Karachi.

MBBS, M.Phil

Assistant Professor

Department of Physiology

 

Sahar Mubeen, Dow International Medical College, Karachi.

MBBS, M.Phil

Associate Professor

Department of Anatomy

Published
2019-10-10