Predictive significance of first trimester serum uric acid as risk factor for the gestational diabetes mellitus.

Authors

  • Anjum Rehman Shaheed Muhtrama Benazir Bhutto Medical College, Layari General Hospital Karachi, Sindh, Pakistan.
  • Sadia Saeed Hamdard Medical University, Karachi, Sindh, Pakistan.
  • Syeda Fariha Hasny Dow University of Health Sciences, Karachi, Sindh, Pakistan.
  • Nathumal Maheshwari Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi, Sindh, Pakistan.
  • Urooj Tabassum Dow University of Health Sciences.
  • Arshad Ali Karachi Institute of Medical Sciences, Malir Cantonment, Karachi, Sindh, Pakistan.

DOI:

https://doi.org/10.29309/TPMJ/2021.28.07.4075

Keywords:

First Trimester, Gestational Diabetes Mellitus, Predictive Significance, Serum Uric Acid

Abstract

Objective: Determining the predictive significance of first trimester serum uric acid for the development of gestational diabetes mellitus (GDM) in pregnant women. Study Design: Case Control study. Setting: Department Gynecology and Obstetrics, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi. Period: March 2017 to December 2018. Material & Methods: Sample of 172 pregnant women in first trimester (<14 weeks gestation) were divided into; 72 controls and 72 cases through purposive sampling. Pregnant women with fasting blood glucose (FBG) ≥100 mg/dl were defined as GDM. FBG was estimated by hexokinase and uric acid by enzymatic method (uricase) using commercial colorimetric assay (Nikken Seal Co., Ltd, Japan). Data was analyzed on SPSS software 21.0 (IBM, Inc USA) at 95% CI. Results: Maternal age of control and cases was noted 30.23±1.47 and 30.14±1.41 years. Gestational age in controls was 9.80±2.23 weeks compared to 10.37±2.34 weeks in cases. Serum Uric acid in control was 3.19±0.49 mg/dl compared to 3.73±0.43 mg/dl in cases (P=0.0001). Logistic regression analysis model generated ROC curve shows excellent area under the curve (AUC) of 0.92 [95% CI (0.87-0.97)] with a diagnostic threshold of 3.91 mg/dl for uric acid. At this Uric acid threshold, the specificity and sensitivity was 96.4% and 69.7% respectively (P=0.0001). Conclusion: It is concluded first trimester serum uric acid may be used for predicting the future development of gestational diabetes mellitus.

Author Biographies

Anjum Rehman, Shaheed Muhtrama Benazir Bhutto Medical College, Layari General Hospital Karachi, Sindh, Pakistan.

MBBS, MCPS, FCPS

Principal Head Gynecology and Obstetrics

 

Sadia Saeed, Hamdard Medical University, Karachi, Sindh, Pakistan.

MBBS, FCPS

Assistant Professor Obstetrics and Gynecology

Syeda Fariha Hasny, Dow University of Health Sciences, Karachi, Sindh, Pakistan.

MBBS, FCPS

Assistant Professor Obstetrics and Gynecology

Nathumal Maheshwari, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi, Sindh, Pakistan.

MBBS, MCPS, FCPS

Assistant Professor Paediatrics

Urooj Tabassum, Dow University of Health Sciences.

MBBS, FCPS

Assistant Professor Psychiatry

Arshad Ali, Karachi Institute of Medical Sciences, Malir Cantonment, Karachi, Sindh, Pakistan.

MBBS, MD

Associate Professor Medicine

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Published

2021-07-10