Effect of zinc supplement on glycemic control and lipid abnormalities in Type 2 diabetic patients.

  • Muhammad Farooq King Abdullah Bin Abdulaziz University Hospital, Princess Noura Bint Abdurrahman University, Riyadh, KSA.
  • Arshad Ali KIMS, Malir Cantt, Karachi.
  • Nayyer Ul Islam KIMS Malir Cantt Karachi.
  • Furquana Niaz KIMS, Malir Cantt Karachi.
  • Yousuf Ul Islam AKU, Karachi.
  • Urooj Tabassum DUHS, OJHA Campus.
Keywords: Glycemic Control, Lipid Abnormalities, Type 2 Diabetes, Zinc Supplementation

Abstract

To evaluate the effects of zinc on glycemic control and lipid profile in type 2 diabetic patients. Objectives: The zinc deficiency is reported in with diabetes, which increases oxidative stresses leading to complications of diabetes. Previous studies demonstrated that zinc supplementation improved glucose control in patients with diabetes, but limited data is available and single blind trials. Study Design: Randomized Controlled study. Setting: Combined Military Hospital (CMH) Malir Cantt, Karachi. Period: 1st December 2018 to 30th June, 2019. Material & Methods: Patients (n=350) were randomly divided into two groups. The first group (n=175) was supplemented with oral zinc sulfate 30 mg/day and second group (n=175) received placebo for a period of 3 months. Blood samples were taken at baseline and after 3 months to assess fasting blood glucose (FBS), glycosylated hemoglobin (HbA1C %) and serum lipid levels and BMI which were compared by t test for paired samples. Results: The mean age of all subjects was 51.80+10.281 years and male to female ratio was 1.08:1. The mean BMI was 31.74+5.806. There was no statistical difference in age and gender between two groups but more obese patient received placebo. The zinc supplemented group had a significant reduction in FBS (p= 0.032) compared to placebo (p= 0.158). The HbA1C% level reduced significantly in zinc supplemented group (p<0.001).compared to the placebo group (p=0.273). Serum lipid levels reduced significantly in the zinc supplemented group (p<0.001) but no significant changes observed in the placebo group (p=0.395). Conclusions: Zinc supplementation improved glycemic control and decreased levels of serum cholesterol, LDL and triglyceride.

Author Biographies

Muhammad Farooq, King Abdullah Bin Abdulaziz University Hospital, Princess Noura Bint Abdurrahman University, Riyadh, KSA.

MBBS, FCPS (Medicine)

Associate Consultant & Associate Professor Internal Medicine

 

Arshad Ali, KIMS, Malir Cantt, Karachi.

MBBS, MD (Medicine)

Associate Professor Medicine

Nayyer Ul Islam, KIMS Malir Cantt Karachi.

BS, FCPS (Medicine)

Professor & Head Medicine

 

Furquana Niaz, KIMS, Malir Cantt Karachi.

MBBS, FCPS (Skin), D-DERM (UK)

Associate Professor & Head Dermatology

 

Yousuf Ul Islam, AKU, Karachi.

MBBS

Resident Surgery

 

Urooj Tabassum, DUHS, OJHA Campus.

MBBS, FCPS (Psychiatry)

Assistant Professor Psychiatry

 

Published
2020-10-10