Prevalence of dyslipidemia in young adults.

  • Mir Tahir Hussain Talpur Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
  • Muhammad Tauqeer Katbar Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
  • Khalil Ullah Shabir Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
  • Kashif Ullah Shabir Indus Hospital, Karachi, Pakistan.
  • Uzair Yaqoob Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
  • Shah Jabeen Liaquat College of Medicine and Dentistry, Karachi, Pakistan,
  • Danish Zia Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
Keywords: Dyslipidemia, Hyperlipidemia, LDL, HDL, Triglyceride, Young Adults

Abstract

Objectives: This study will help us to understand what lipid profile is normally present in our population, if abnormal, timely screening, education, and proper management can be done. Study Design: Cross-sectional study. Setting: Jinnah Postgraduate Medical Centre (JPMC), Karachi, Pakistan. Period: November 2018-April 2019. Material & Methods: For the lipid profile, intravenous blood samples were collected in testing bottles after overnight fasting of 9-12 hours and sent to the institutional laboratory for testing. Dyslipidemia was defined as abnormal levels of any of the following components of the lipid profile. Total cholesterol of <200mg/dL was considered “desirable” while that of >240mg/dL was termed as hypercholesterolemia. High-density lipoprotein (HDL) was considered as “low” when it was <40mg/dL while Low-density lipoprotein (LDL) was considered as “optimal” when it was less than 100 mg/dL. Triglycerides level >150 mg/dL was identified as hypertriglyceridemia. We defined isolated dyslipidemias as abnormal levels of any of these. This study was assessed and approved by the institutional review board of JPMC. Results: 112 participants of age <40 and >20 years were registered with 62 males and 50 females. Prevalence of dyslipidemia was found to be 75.9% with significantly high percentage in females (p < 0.05). 55.4% of the participants had desirable serum cholesterol and 42.9% had hypertriglyceridemia. 58% of these had HDL levels <40 mg/dL while 18.8% had high LDL levels. The mean serum cholesterol was significantly different in males and females (p=0.018). 7.1% of the total had isolated hypertriglyceridemia, 18.8% had isolated low HDL levels, and 46.4% had mixed hyperlipidemia, with significant differences between males and females in the former two. Conclusion: Dyslipidemia is a major risk factor for numerous systemic disorders and should be detected early in life for an effective management prior to the appearance of symptoms. This study gave a high prevalence of dyslipidemia in asymptomatic young adults, with females being more frequently affected than females.

Author Biographies

Mir Tahir Hussain Talpur, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

FCPS

Assistant Professor

 

Muhammad Tauqeer Katbar, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

FCPS

Consultant

 

Khalil Ullah Shabir, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

MBBS

Postgraduate Resident

 

Kashif Ullah Shabir, Indus Hospital, Karachi, Pakistan.

FCPS

Consultant

 

Uzair Yaqoob, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

MBBS

House Officer

 

Shah Jabeen, Liaquat College of Medicine and Dentistry, Karachi, Pakistan,

M.Phil

Assistant Professor

 

Danish Zia, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

MBBS

Postgraduate Resident

 

Published
2020-05-10