Therapeutic effect of mango seed extract in diabetes mellitus.

  • Arfa Azhar Aga Khan University Hospital.
  • Kausar Aamir Basic Medical Sciences Institute Karachi.
  • Farah Asad Jinnah Sindh Medical University Karachi.
  • Hamid Ali Kazi Institute of Pharmaceutical Sciences, Peoples University of Medical and Health Sciences for Women, PUMHSW, Nawabshah.
  • Mohammad Umair Farooqui Shaeed Muhtarma Benazir Bhutto Medical University, Larkana.
Keywords: Alloxane, Diabetes Mellitus, Mango Seed, Tolbutamide

Abstract

Background: Diabetes mellitus is very common disease; the oral hypoglycemic drugs are utilized for diabetes. In Asia therapeutic plants are extensively used for cure of widespread variation of illnesses. Objectives: To study the Therapeutic effect of mango seed extract on diabetes Mellitus. Study Design: A prospective study and longitude. Setting: This study was conducted at Jinnah Post graduate Center, Karachi. Period: From June 2016 to June 2017. Material and Methods: Mango seeds were taken out with ethanol and used for study. The antidiabetic action of mango seeds extracts were well-thought-out at 100 and 200 mg/kg b.wt. The antidiabetic effect of mango seeds extracts were matched with tolbutamide 500 mg/kg b.wt. Result: The ethanolic extract of mango seeds (200 mg/kg) revealed major (p< 0.01) hypoglycemic outcome in fasted diabetic rats, when matched with normal control group. The mango seed extracts were significantly increased insulin level and decreased HbA1c levels at the dose level (100, 200 mg/kg) in alloxone encouraged diabetic rats. Conclusion: The ethanolic extract of mango seeds ensuring important antidabatic outcome compared to aloxone tempted diabetes in albino rats and its stimulating insulin production in pancreas of albino rats.

Author Biographies

Arfa Azhar, Aga Khan University Hospital.

MBBS, M.Phil

Senior Instructor

Department of Biological and Biomedical Sciences

 

Kausar Aamir, Basic Medical Sciences Institute Karachi.

MBBS, M.Phil, PhD.

Professor and Head

Department of Pharmacology and Therapeutic

 

Farah Asad, Jinnah Sindh Medical University Karachi.

MBBS, M.Phil, PhD.

Associate Professor

Department of Pharmacology and Therapeutic

 

Hamid Ali Kazi, Institute of Pharmaceutical Sciences, Peoples University of Medical and Health Sciences for Women, PUMHSW, Nawabshah.

PhD.

Professor and Director

 

Mohammad Umair Farooqui, Shaeed Muhtarma Benazir Bhutto Medical University, Larkana.

M.Phil. (Microbiology)

Lecturer

Department of Pharmacy

 

Published
2019-09-10