Comparison of effect of aloe Vera gel with aspirin and celecoxib on platelet aggregation.

  • Sidra Mushtaq Independent University Hospital Faisalabad.
  • Zobia Mushtaq Punjab Medical College Faisalabad.
  • Javeria Arif King Edward Medical College Lahore
  • Mufakhara Fatima Sahara Medical College Narowal.
  • Sadida Bahawal Independent University Hospital Faisalabad.
  • Qura-tul- Ain Red Crescent Medical and Dental College, Lahore.
  • Sadia Chiragh AL-Aleem Medical College, Lahore.
Keywords: Anti-Platelet, Aloe Vera, Aspirin, Celecoxib

Abstract

Objective: This study was designed to compare the effect of Aloe vera gel with aspirin and celecoxib on platelet aggregation. Study Design: Comparative Study. Setting: Post graduate Medical Institute Lahore, Children Hospital, Lahore. Period: September 2015 to September 2016. Material & Methods: Blood was withdrawn from anti-cubital vein, complete blood count was checked, platelet rich plasma was prepared by centrifuging citrated whole blood and then incubated with  Aloe vera low (AVL), Aloe vera high (AVH), aspirin and celecoxib for 30 minutes at 37C. After adding the agonist arachidonic acid, reading was then taken for 3 minutes and percentage aggregation was recorded. Results: Platelet aggregation with aspirin, AVH and AVL was statistically significantly lower as compared to control and celecoxib groups. Conclusion: This study has demonstrateda dose dependentanti-platelet effect of Aloe vera gel which is comparable to aspirin.

Author Biographies

Sidra Mushtaq, Independent University Hospital Faisalabad.

M.Phil Pharmacology

Assistant Professor Pharmacology

Zobia Mushtaq, Punjab Medical College Faisalabad.

M.Phil (Pharmacology)

Assistant Professor Pharmacology

 

Javeria Arif, King Edward Medical College Lahore

M.Phil (Pharmacology)

Assistant Professor Pharmacology

 

Mufakhara Fatima, Sahara Medical College Narowal.

M.Phil (Pharmacology)

Assistant Professor Pharmacology

 

Sadida Bahawal, Independent University Hospital Faisalabad.

MBBS, FCPS

Professor Pediatric

 

Qura-tul- Ain, Red Crescent Medical and Dental College, Lahore.

M.Phil Pharmacology

Assistant Professor Pharmacology

 

Sadia Chiragh, AL-Aleem Medical College, Lahore.

M.Phil (Pharmacology)

Professor Pharmacology

 

Published
2020-05-10