Role of simvastatin and allium sativum on lipid profile in diabetic dyslipidemic patients: a comparative study.

  • Naveed Ali Siddiqui United Medical & Dental College, Karachi, Pakistan.
  • Fatima Bint Taj United Medical & Dental College, Karachi, Pakistan.
  • Imran Ishaque United Medical & Dental College, Karachi, Pakistan.
  • Ayesha Shahid United Medical & Dental College, Karachi, Pakistan.
  • Ayesha Ayaz United Medical & Dental College, Karachi, Pakistan
Keywords: Allium Sativum, Dyslipidemia, Lipid Profile, Simvastatin

Abstract

Objectives: To evaluate the changes in lipid profile in patients with diabetic dyslipidemia using lipid lowering drug, simvastatin and herbal product allium sativum. Study Design: Clinical trial. Setting: Surgeon Munawar Memorial Hospital, Karachi. Period: 1st January 2017 to 30th April 2017. Material & Methods: The study was designed to assess the effects of hmg-coa reductase inhibitor (simvastatin) and allium sativum on lipid profile in patients with diabetic dysplipidemia. The exclusion criteria included lactating/pregnant women’s, renal, liver and established coronary artery disease. Results: Sixty patients with abnormal lipid profile were included in the study (age 30-60 years). Patients were divided into two groups (30 patients each). Group a was orally administered with product of simvastatin (20 mg)/day for 04 months and in group b, patients were orally administered with herbal product of allium sativum (300 mg)/day for 04 months. Conclusion: On the basis of this study it is observed that allium sativum as well as simvastatin tablets both reduce total cholesterol, low density lipoprotein cholesterol (ldl-c) and increase high density lipoprotein cholesterol (hdl-c).

Author Biographies

Naveed Ali Siddiqui, United Medical & Dental College, Karachi, Pakistan.

MBBS, M. Phil, P.hD

Associate Professor Biochemistry,

 

Fatima Bint Taj, United Medical & Dental College, Karachi, Pakistan.

Final year student, UMDC

 

Imran Ishaque, United Medical & Dental College, Karachi, Pakistan.

MBBS, M.Phil

Associate Professor Biochemistry,

 

Ayesha Shahid, United Medical & Dental College, Karachi, Pakistan.

Final Year Student, UMDC

 

Ayesha Ayaz, United Medical & Dental College, Karachi, Pakistan

Final Year Student, UMDC

 

Published
2020-02-10