Comparative study of effectiveness of vitamin E and evening primrose oil for pain relief in moderate cyclical mastalgia.

  • Ramlah Ghazanfor Holy Family Hospital Rawalpindi Medical University.
  • Usman Qureshi Holy Family Hospital Rawalpindi.
  • Rafay Ghazanfer Adil CMH, Lahore.
  • Sara Malik Holy Family Hospital Rawalpindi. Rawalpindi Medical University
  • Maham Tariq Holy Family Hospital Rawalpindi Rawalpindi Medical University.
  • Jahangir Sarwar Khan Holy Family Hospital Rawalpindi Medical University
Keywords: Cyclical Mastalgia, Evening Primrose Oil, Gamma linolenic acid (GLA), NSAIDs, Vitamin E

Abstract

In breast clinics worldwide, cyclical mastalgia is the commonest presenting complaint among patients of reproductive age. Non-pharmacological options are preferred mode of treatment due to their better side effect profile. This study compares the effectiveness of two such non-pharmacological options i.e. Vitamin E and Evening Primrose Oil. Study Design: Randomized controlled single blinded trial. Setting: Surgical Unit 1 Holy Family Hospital, Rawalpindi. Period: Six months from July to Dec 2017. Materials and Methods: Observing all scientific and ethical protocols. All non-pregnant and non-lactating females of reproductive age were included in study. Two groups A and B, of 190 patients each, were made. Group A received Vitamin E capsules 400 mg once daily whereas group B received evening primrose oil 500 mg capsules twice daily. After six months, mean reduction in pain scores in both groups was calculated using a t-test (p-value < 0.05 was considered significant). Results: Total number of 380 female patients (190 in each group) were enrolled in study for a period of 6 months. Mean age was 30.00+16.54 years. Mean score at presentation was 5.69+0.08 in vitamin E group and 5.66+0.8 in EPO group. After 6 months, score was 3.70+1.5 in vitamin E group and 4.78+1.47 in EPO group, which was statistically significant (p value < 0.05). Conclusion: Vitamin E, when taken for 6 months, is more effective than evening primrose oil in reducing pain in moderate cyclical mastalgia.

Author Biographies

Ramlah Ghazanfor, Holy Family Hospital Rawalpindi Medical University.

FCPS General Surgery

Registrar

Department of Surgical Unit 1

 

Usman Qureshi, Holy Family Hospital Rawalpindi.

FCPS General Surgery

Assistant Professor

Department of Surgery Surgical Unit 1

 

Rafay Ghazanfer Adil, CMH, Lahore.

Third Year MBBS

Medical Student

 

Sara Malik, Holy Family Hospital Rawalpindi. Rawalpindi Medical University

Post Graduate Trainee

Department of Surgical Unit 1

 

Maham Tariq, Holy Family Hospital Rawalpindi Rawalpindi Medical University.

Post Graduate Trainee

Department of Surgical Unit 1

 

Jahangir Sarwar Khan, Holy Family Hospital Rawalpindi Medical University

MBBS, FCPS, FRCS, FACS, FICS, DIP. M.ED

Professor of Surgery

Department of Surgical Unit 1

 

Published
2019-08-10