HYPERURICEMIA

A RISK FACTOR FOR DEVELOPMENT OF HYPERTENSION IN PAKISTANI COMMUNITY.

Abstract

Objectives: To determine the association of hyperuricemia with hypertension.
Study Design: Case-control study. Place and Duration of Study: Out-patient department of
Fuji foundation hospital, Rawalpindi. The study conducted over a period of six months from 1st
February 2012 till 31st July 2012. Methodology: 268 patient were selected for study and divided
into two groups on the basis of presence or absence of hypertension (group 1 comprised
of newly diagnosed hypertensive patients and group 2 comprised normotensive individuals).
Each group comprised 134 patients fulfilling inclusion/ exclusion criteria. Serum uric acid levels
were checked and compared in both groups. Results: In hypertensive group, the minimum
age was 20 years and the maximum age was 100 years with a mean age of 50.76. Minimum
uric acid level was 193/literμmol and maximum uric acid level was 608 μmol/L with a mean of
316.87. In non-hypertensive group, minimum age was 20 years and the maximum age was
80 years with a mean age of 47.84. The minimum uric acid level was 125μmol /L and the
maximum was 404μmol/L with a mean of 273.24. The P-value was 0.000 which means that the
difference between the two groups was statistically significant. Conclusion: There is statistically
significant association of hyperuricemia with hypertension. More studies are recommended to
establish this fact.