PROPHYLAXIS OF POSTOPERATIVE NAUSEA AND VOMITING LAPAROSCOPIC PROCEDURES WITH 5-HT3 RECEPTOR ANTAGONISTS, A RANDOMIZED CONTROLLED TRIAL.

  • Maqsood Ahmed Siddiqui GMC Hospital Sukkur.
  • Ahmed Uddin Soomro Chandka Medical College, Larkana.
  • Hamid Raza Liaquat University of Medical and Health Sciences Jamshoro.
  • Kamlaish - Dow University of Health Sciences, Civil Hospital Karachi.
Keywords: Anti-Emesis, Laparoscopy, Palonosetron, Post-Operative Nausea and Vomiting, Ramosetron

Abstract

Objectives: In this study we aim to study the efficacy of Ramosetron and Palonosetron in preventing post-operative nausea and vomiting in high risk patients. Study Design: A randomized controlled trial. Setting: A Large Tertiary Care Centre in Karachi. Period: 9 months from January 2017 to September 2017. Method: N=81 participants took part in the study. The patient population was divided into three groups.. Patients belonging to group A received Palonosetron 0.075mg mixed with normal saline in a mixture of 3ml, prior to induction, and received 3ml of normal saline half an hour prior to the end of the procedure. Patients in group B received 3ml of normal saline prior to induction and a mixture of 0.3mg of Ramosetron mixed with normal saline as 3ml half an hour before end of procedure. In group C patients received normal saline 3ml both before induction and half an hour prior to end of surgery. Results: The patient demographics were similar in all the groups and no significant difference was found. The incidence of post-operative nausea and vomiting during 2 hours post operatively was 41.97%, the incidence of nausea at 2 hours was in group A= 33.33%, in group B= 29.62%, in group C= 62.96% respectively, having a p value of 0.014 refer to table 2. After 48 hours of surgery the overall incidence of vomiting in the groups was not significant having a p value of 0.428 and an incidence of 6.172%. Conclusion: Palonosetron and Ramosetron are equally effective in prevention of post-operative nausea and vomiting in high risk patients undergoing laparoscopic gynecological procedures.

Author Biographies

Maqsood Ahmed Siddiqui, GMC Hospital Sukkur.

MBBS, MCPS, FCPS, M.Sc Pain Medicine

Assistant Professor & Head

Department of Anesthesiology

Surgical ICU & Pain Management,

 

Ahmed Uddin Soomro, Chandka Medical College, Larkana.

MBBS, FCPS

Assistant Professor

Department of Anesthesia & Surgical ICU

 

Hamid Raza, Liaquat University of Medical and Health Sciences Jamshoro.

MBBS, FCPS

Assistant Professor

Department of Anesthesiology & ICU

 

Kamlaish -, Dow University of Health Sciences, Civil Hospital Karachi.

MBBS, FCPS

Consultant

Department of Anesthetist

 

Published
2019-07-10