EFFECTIVENESS OF SINGLE DOSE INTRAVESICAL MITOMYCIN C THERAPY AS PROPHYLAXIS TO PREVENT RECURRENCE AND PROGRESSION OF SUPERFICIAL NONMUSCLE INVASIVE BLADDER TUMOR.

  • Sherjeel Saulat Head of Department Tabba Kidney Institute Karachi Pakistan.
  • Anees Ur Rehman Soomro Tabba Kidney Institute Karachi Pakistan.
  • Muhammad Murtaza Azad Tabba Kidney Institute Karachi Pakistan.
Keywords: Intravesical, Mitomycin C, Recurrence, Superficial Non-Muscle Invasive Bladder Tumor, TUR (BT)

Abstract

Objectives: To determine the effectiveness of instillation of single dose of intravesical mitomycin C in patients with low grade non-muscle invasive bladder tumor (NMIBT). Study Design: Retrospective cross-sectional study. Setting: Tabba kidney institute Karachi. Period: 2016 to Jan-2018. Subject and Methods: A total of 76 patients with first time diagnosis of non-invasive bladder tumor were included. Data of patients of SNMIBT who underwent trans-uretheral resection of bladder tumor (TURBT) and received single dose instillation of mitomycin C (MMC, 40 mg) within 24 hours after resection from 2016 to Jan-2018 were included in this analysis. All these patients were followed for 6 months after TURBT, cystoscopy was performed at 3 and 6 monthly to check and record any recurrence or progression. Results: Out of 76 cases, 43 (56.57%) had one lesion, 27 (35.52%) had two lesion and 6 (7.89%) cases had three lesion. Single dose intravesical mitomycin C was effective in 81.57% (62/76) cases, recurrence occurred in 6 (7.89 %) cases and progression of disease in 8 (10.52%) cases. Conclusion: The results of present study confirmed the positive effect of instillation of single immediate dose of MMC in patients with low risk superficial bladder tumor. 81.57% patients will not require any further treatment if MMC-40 is given immediately following TURBT.

Author Biographies

Sherjeel Saulat, Head of Department Tabba Kidney Institute Karachi Pakistan.

FCPS Urology, FEBPU,

Dip. Laparoscopic Urology,

Fellowship in Pediatric Urology

 

Anees Ur Rehman Soomro, Tabba Kidney Institute Karachi Pakistan.

FCPS Urology

Lecturer

 

Muhammad Murtaza Azad, Tabba Kidney Institute Karachi Pakistan.

FCPS Urology

Senior Registrar

Department of Urology

 

Published
2019-07-10