Influence of serum estradiol on serum uric acid level in pre and postmenopausal women.

  • Rahat Naseem King Edward Medical University Lahore. 
  • Sardar Muhammad Al-Fareed Zafar Ameer ud Din Medical College/PGMI.
  • Samia Jawed Continental Medical College 
  • Saima Mukhtar Rahbar Medical and Dental College Lahore.
  • Farhat Ijaz CMH LMC & IOD (NUMS) Lahore.
  • Rana Khurram Aftab KEMU Lahore.
Keywords: Hyperuricemia, Postmenopause, Premenopause, Serum Estradiol, Serum Uric Acid


Background: Hyperuricemia develops when serum uric acid level exceeds the normal value. Estrogen may influence the level of serum uric acid. Postmenopausal females have a remarkable reduction in its level, so serum estradiol is studied in relation to serum uric acid levels in pre and post-menopausal women. Objective: To find out the relationship of serum Estradiol with serum uric acid level in premenopausal and postmenopausal women in local population. Study Design: Case control study. Setting: This study was conducted in Lady Aitchison Hospital Lahore. Period: March 2017- August 2017. Material and Methods: 134 females were enrolled in total and were grouped in to two. Group A comprised of premenopausal and Group B included postmenopausal females. After complete history and general physical examination, 5 ml venous blood sample under aseptic measures was taken. Serum uric acid was measured by enzymatic and serum estradiol by Enzyme-linked immunosorbent assay method. Results: The mean age of pre and postmenopausal women was 32 and 57 ± 7 years, with significantly lower in premenopause. The mean serum E2 was 91.86 ± 26.71 mg/dL in premenopause and 22.04 ± 9.28 mg/dL in postmenopause, with significantly lower mean in postmenopause. Mean serum uric acid was statistically higher in postmenopause that was 6.04 ± 0.58 mg/dL, when compared to premenopause that was 4.22 ± 0.90 mg/dL. Conclusion: Serum uric acid levels increased due to decreased serum estradiol in postmenopausal women as compared to premenopausal women.

Author Biographies

Rahat Naseem, King Edward Medical University Lahore. 

MBBS, M.Phil Physiology 


Department of Physiology 


Sardar Muhammad Al-Fareed Zafar, Ameer ud Din Medical College/PGMI.

FCPS, MCE, FRCOG, Fellowship in RE



Samia Jawed, Continental Medical College 
  1. Phil Physiology 


Department of Physiology 


Saima Mukhtar, Rahbar Medical and Dental College Lahore.

M.Phil Physiology

Associate Professor

Department of Physiology 


Farhat Ijaz, CMH LMC & IOD (NUMS) Lahore.


Assistant Professor

Department of Physiology


Rana Khurram Aftab, KEMU Lahore.


Assistant Prof

Department of Physiology