Reproductive Hormone in Transfusion dependent βeta thalassemia major patients.

  • Sana Fatima Baloch Bilawal Medical College.
  • Ikram Din Ujjan LUMHS, Jamshoro.
  • Sadia Shahmeer Bilawal Medical College
  • Nazia Hafeez Bilawal Medical College.
  • Kiran Amir LUMHS, Jamshoro.
  • Abdul Rehman LUMHS, Jamshoro.
Keywords: Beta-thalassemia major, Endocrine Profile

Abstract

Objective: To evaluate endocrine profile in transfusion dependent beta-thalassemia major patients. Study Design: Descriptive cross sectional study. Setting: Department of Pathology Liaquat University of Medical and Health Sciences, Jamshoro /Hyderabad and Thalassemia Centre Hyderabad. Period: 6 months from January 2018 to June 2018. Material & Methods: Cases already diagnosed with β- thalassemia major with recurrent blood transfusions (>20 transfusions or transfusion period over 2 years) both genders were included. All the patients went through routine laboratory checkups including Testosterone hormone, Luteinizing Hormone, and Follicle Stimulating Hormone. Data was recorded in preplanned proforma. Results: Overall 114 subjects were studied and their mean age was found to be 12.38+5.71 years. Females remained in majority as 56.1%. Mean of follicle stimulate hormone (FSH) and luteinizing hormone (LH) level were 4.60+4.88 and 5.39+8.39 respectively. Most of the patients, 35.1% had >300 of transfusion rate. Ferritin levels were significantly correlated with patients with history of transfusion rate >300; p-value 0.003. Testosterone level’s mean was considerably high among patients presented with transfusion rate of 201 to 300 and >300 transfusions; p-value 0.006. Likewise, mean of FSH and LH level was as well significantly high among the female subjects with history of transfusion rate of 201 to 300 and >300 transfusions; P-Values 0.019 and 0.026 respectively. Conclusion: Frequent hypogonadism was noted among thalassemia patients. Very low level average of FSH, LH and testosterone was seen.

Author Biographies

Sana Fatima Baloch, Bilawal Medical College.

MBBS, M.Phil

Lecturer

Department of Pathology

 

Ikram Din Ujjan, LUMHS, Jamshoro.

P.hD

Professor

Department of Pathology

 

Sadia Shahmeer, Bilawal Medical College

MBBS, M.Phil

Lecturer

Department of Pathology

 

Nazia Hafeez, Bilawal Medical College.

MBBS, M.Phil

Lecturer

Department of Pathology

 

Kiran Amir, LUMHS, Jamshoro.

MBBS, M.Phil

Assistant Professor

Department of Pathology

Abdul Rehman, LUMHS, Jamshoro.

MBBS, M.Phil

Lecturer

Department of Pathology

 

Published
2019-12-10