Effect of haloperidol on centrilobular vein and portal triad of liver in the albino rats during intrauterine life

Abstract

Haloperidol is first generation antipsychotic used to treat psychosis. Its usage during pregnancy benefits psychotic mother and is indispensable for treating psychiatric emergency situations. Objectives: To evaluate the effects of haloperidol on development of centrilobular vein and portal triad of liver given to albino rats during intrauterine period. Study Design: Experimental study. Setting: PPGMI Animal House, Lahore. Period: July to September 2017. Materials & Methods: Pregnant female rats were randomly divided into three groups A,B and C ,15 rats in each group. Group B & C were given haloperidol in a dose of 0.4mg/kg and 0.8mg/kg body weight by intraperitoneal route whereas group A was considered as control group. Hysterotomy was done on 21^st day of gestation and pups were removed. Pups of group A, B and C were designated as A1, B1 and C1. They were grossly examined for any abnormality and liver was removed after dissection. Slides were made and stained to evaluate changes in detailed histological study of centrilobular veins and portal triads. Results: Comparison of centrilobular vein and portal triad of group B1 and C1 with control A1 revealed that there is significant congestion seen in centrilobular veins of group B1 and C1 with P value ≤ 0.001 and signs of inflammation are present in experimental groups where were significant as compared to control group A1 with P value ≤ 0.001. Conclusion: Haloperidol, given during intrauterine life is responsible for initiating cell injury sequelae in the developing liver of fetal albino rats and must be given with caution if necessary.