ANTIDIABETIC EFFECT OF GUAIACUM OFFICINALE

ON EXOCRINE FUNCTION AND HISTOPATHOLOGY OF PANCREAS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Authors

  • Sadaf Ibrahim Baqai Medical University, Karachi.
  • S.N.H. Naqvi Baqai Medical University, Karachi.
  • Rehana Perveen Baqai Medical University, Karachi.
  • Hina Abrar Dow University of Health Sciences Karachi.
  • Zuneera Akram Baqai Medical University, Karachi.

DOI:

https://doi.org/10.29309/TPMJ/2018.25.04.360

Keywords:

Diabetes, Streptozotocin, Glibenclamide, Lipase, Amylase

Abstract

Introduction: Diabetes is the most genetically transmitted disease all over the
world. It badly affects the vital organs and manifest the reduction of pancreatic amylase and
lipase. Objectives: This study has been designed to investigate the role of Guaiacum officinale
extract in controlling of diabetes in streptozotocin (STZ) induced type 2 diabetes male albino
(Wistar) rats. Study Design: Experimental. Setting: Baqai Medical University. Period: January
2017- June 2017. Method: Bark extract of Guaiacum officinale (500mg/kg) was administered
to STZ induced rat. Glibenclamide (GLB) was used as standard drug. The approach of the
study was to observe the effect of Guaiacum officinale on pancreatic amylase and lipase and its
tissue architecture by histopathology. Rats were divided in four groups i-e control, STZ treated,
STZ + GLB treated and STZ +extract treated group. Results: Guaiacum officinale significantly
improve the level of pancreatic amylase and lipase as compared to the STZ induced group.
Similarly the pancreatic architecture was significantly affected by STZ alone. These changes
were considerably reversed by Guaiacum officinale and GLB. Conclusion: It was concluded
that Guaiacum officinale herb useful to cure the diabetes and it is effective in protecting pancreas
from diabetes induced damages.

Author Biographies

Sadaf Ibrahim, Baqai Medical University, Karachi.

B.Pharm (RPh),
M.Pharm, Ph.D. Fellow
Assistant Professor
Department of Pharmacology,

S.N.H. Naqvi, Baqai Medical University, Karachi.

Ph. D. D. Sc
Professor
Department of Pharmacology,

Rehana Perveen, Baqai Medical University, Karachi.

B.Pharm (RPh), Ph.D
Professor
Department of Pharmacology,

Hina Abrar, Dow University of Health Sciences Karachi.

Pharm. D (RPh), M.Pil, Ph.D
Assistant professor
Department of Pharmacology,

Zuneera Akram, Baqai Medical University, Karachi.

Pharm.D (RPh), M.Phil
Senior Lecturer
Department of Pharmacology,

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Published

2018-04-10