BACTERIAL PNEUMONIA;

CORRELATION BETWEEN LABORATORY MARKERS (C REACTIVE PROTEIN, WHITE BLOOD CELLS) AND TREATMENT FAILURE WITH ORAL AMOXICILLIN IN BACTERIAL PNEUMONIA IN CHILDREN AGED 2-59 MONTHS OLD.

  • Muhammad Nadeem Chohan LUMHS, Jamshoro.
  • Salma Shaikh Liaquat University of Medical and Health Sciences Jamshoro.
  • Saleem Shaikh LUMHS Jamshoro.
  • Zubair Memon LUMHS Jamshoro.
  • Yasmin Memon LUMHS Jamshoro.
Keywords: CRP, WBC, Pneumonia, Children

Abstract

Objectives: To assess the correlation between laboratory markers (C Reactive Protein, White Blood Cells) and treatment failure with Oral Amoxicillin in Bacterial Pneumonia in children aged 2-59 months old at Pediatrics Emergency Department LUMHS Hyderabad. Study Design: Cross sectional study. Setting: Department of Pediatric Emergency LUMHS, Civil Hospital Hyderabad. Period: November 2015 to May 2016. Methodology: A total of 80 children aged 2-59 months old were treated with Oral Amoxicillin 90mg/kg/day for 5 days and response to treatment was assessed on 3rd day of admission. Blood was drawn from the veins over the dorsum of either hand at initial visit for C Reactive Protein and WBC Count. Children who do not improve on 3rd day of admission were declared treatment failure and switched to 2nd line treatment that is Injection Ceftriaxone. Results: In this study overall 78.7% children improved with Oral Amoxicillin 90mg/kg/day BD for 5 days, while 16.3% children had treatment failure on Oral Amoxicillin. 5% children were defaulted due to parents concerns. Conclusion: C Reactive Protein is a valuable marker that can predict the response of Oral Antibiotics in bacterial Pneumonia in children. Cost effectiveness can be determined by further studies, hence to justify that which children with Bacterial Pneumonia should be treated with 2nd line Injectable antibiotics from very beginning of treatment.

Author Biographies

Muhammad Nadeem Chohan, LUMHS, Jamshoro.

MBBS, FCPS

Senior Registrar

Pediatrics Department

 

Salma Shaikh, Liaquat University of Medical and Health Sciences Jamshoro.

MBBS, FRCP 

Dean and Head

Department of Pediatric

 

Saleem Shaikh, LUMHS Jamshoro.

MBBS

Research Officer

Department of Pediatric

 

Zubair Memon, LUMHS Jamshoro.

MBBS

Resident

Department of Pediatrics

 

Yasmin Memon, LUMHS Jamshoro.

MBBS, FCPS

Chairman

Department Pediatric

Published
2019-05-10