COMPARISON OF HEMODYNAMIC CHANGES ON USING PROPOFOL AS TOTAL IV INDUCTION AND BALANCED ANESTHESIA TECHNIQUE (THIOPENTONE, NITROUS OXIDE AND ISOFLURANE).
Introduction: Porpofol is currently available popular intravenous anaesthetic agent. It is widely used for induction and maintenance of anaesthesia. Its main advantages are rapid induction and recovery, antiemetic and anticonvulsant effects. It has been used successfully for tracheal intubation without muscle relaxant, day surgery and for insertion of laryngeal mask airway. Its main disadvantages are pain on injection, dose dependent hypotension and severe bradycardia after induction. Objectives: The objective of the study was to compare mean hemodynamic changes using propofol as total intravenous anaesthesia with balanced anaesthesia technique (thiopentone-isoflurane-nitrousoxide). Setting: Department of Anaesthesia, Allied Hospital, Faisalabad. Duration: 6 months after approval of synopsis, from 18-7-2014 to 17-1-2015. Study Design: Randomized control trial. Results: In our study, out of 60 cases(30 in each group), 70%(n=21) in Group-A and 63.33%(n=19) in Group-B were between 12-30 years of age while 30%(n=9) in Group-A and 36.67%(n=11) in Group-B were between 31-60 years of age, mean+sd was calculated as 27.90+8.91 and 29.8+8.49 years respectively. 60%(n=18) in Group-A and 53.33%(n=16) in Group-B were male while 40%(n=12) in Group-A and 46.67%(n=14) in Group-B were females. Comparison of mean hemodynamic changes using propofol as total intravenous anaesthesia with balanced anaesthesia technique (thiopentone-isoflurane-nitrous oxide) shows that heart rate after intubation in Group-A was 83.4+2.36 and 90.36+1.95 in Group-B, p value was 0.001 while mean arterial pressure in Group-A was recorded as 78.6+2.25 and in Group-B 89.43+1.73, p value was 0.000. Conclusion: Propofol as total intravenous anaesthesia shows significanly better stability in haemodynamics when comapred with balanced anaesthesia technique (thiopentone-isoflurane-nitrous oxide) in surgical procedures.