Hyperuricemia in Systemic Hypertension and its correlation with systolic and diastolic blood pressure.

  • Haji Khan Khoharo Isra University, Hyderabad, Sindh, Pakistan.
  • Ali Akbar Shah Indus Medical College Tando Muhammad Khan, Sindh.
  • Fatima Qureshi Bilawal Medical College, LUMHS, Jamshoro, Sindh, Pakistan.
  • Sajjad Ali Almani Isra University, Hyderabad, Sindh, Pakistan.
Keywords: Diastolic BP, Hyperuricemia, Systemic Hypertension, Systolic BP

Abstract

Objectives: To determine the serum uric acid (SUA) in systemic hypertension and its correlation with systolic (SBP) and diastolic blood pressure (DBP). Study Design: Cross sectional study design. Setting: Department of Medicine, Isra University Hospital. Period: From April 2016 – February 2017. Material and Methods: A sample of 100 cases of systemic hypertension and 100 age, gender, body weight and BMI controls were selected through non-probability purposive sampling. Volunteers were asked for history, physical examination, and blood sampling. Systemic BP was measured with a mercury sphygmomanometer. 2 ml venous blood was taken, centrifuged and sera were used for detection of SUA. Data was saved in a pre- structured Performa. Computed based statistical software (SPSS v 22.0, IBM, Incorporation, USA) was used for data analysis. Data variables were analyzed at 95% CI (P ≤ 0.05). Results: Serum uric acid in controls was 2.91±0.75 mg/dl compared to 5.70±1.76 mg/dl (P=0.0001). 57% of cases revealed hyperuricemia compared to 11% in control (X2=17.5, P=0.0001). Serum Uric acid showed significantly positive correlation with Systolic BP (r= 0.518*, p=0.0001) and Diastolic BP (r= 0.397**, p=0.0001). Conclusion: The present study reports hyperuricemia in 57% cases of systemic hypertension and uric acid shows positive correlation with systolic and diastolic blood pressure.

Author Biographies

Haji Khan Khoharo, Isra University, Hyderabad, Sindh, Pakistan.

MBBS, M. Phil, FCPS

Associate Professor

Faculty of Medicine and Allied Medical Sciences

 

Ali Akbar Shah, Indus Medical College Tando Muhammad Khan, Sindh.

MBBS, M. Phil, Ph.D

Associate Professor

Department of Biochemistry

 

Fatima Qureshi, Bilawal Medical College, LUMHS, Jamshoro, Sindh, Pakistan.

MBBS, M. Phil

Assistant Professor

Department of Biochemistry,

 

Sajjad Ali Almani, Isra University, Hyderabad, Sindh, Pakistan.

MBBS, M.Phil

Assistant Professor

Department of Anatomy

 

Published
2020-01-10