Antistreptolysin O titer and C-reactive protein levels in pediatric patients of acute rheumatic fever.

Authors

  • Sana Zainab Pakistan Kidney and Liver institute and Research Center Lahore.
  • Nida Saleem Pakistan Kidney and Liver institute and Research Center Lahore.
  • Adil Manzoor Pakistan Kidney and Liver institute and Research Center Lahore.
  • Saba Khaliq University of Health Sciences Lahore.
  • Anum Wasim Pakistan Kidney and Liver institute and Research Center Lahore.
  • Shakila Khaliq Rahim Yar Khan.
  • Farhana Shehzad The Children's Hospital and Institute of Child Health.

DOI:

https://doi.org/10.29309/TPMJ/2020.27.08.3336

Keywords:

Acute Renal Failure, Antistreptolysin O Titer, C-reactive Protein

Abstract

Objectives: To determine serum levels of antistreptolysin O titre (ASOT) and C-reactive protein (CRP) and their association with clinical manifestations of Acute rheumatic fever (ARF). Study Design: Descriptive study. Setting: Department of Diagnostic Immunology and Serology, Children’s Hospital and Institute of Child Health, Lahore. Period: Jan 2015 to Jan 2016. Material & Methods: Fifty clinically confirmed patients of ARF were included in this descriptive study. The samples were taken from Children hospital and Institute of child health Lahore after written informed consent. The sampling technique was convenient sampling. Results: Out of 50 enrolled patients, males were 32(64%) and women 18(36%). Only 5(10%) patients had normal ASOT levels, 20(40%) patients were with borderline ASOT, and 25(50%) patients had titres above 200 IU/ml. There was no significant association of ASOT with gender, age and arthralgia with p-value = 0.060, 0.875 and 0.473, respectively. However, a significant association was found in ASOT with carditis and C-reactive protein (p-value = 0.028 and 0.014, respectively). Only 3 (6%) patients had CRP levels below 6mg/l, whereas 43 (86%) patients were with CRP levels above 6. Only 4(8%) patients had borderline value of CRP titer. There was no significant association between C-reactive protein with gender, age and arthralgia (p-value = 0.148, 0.184 and 0.574, respectively). Moreover, there was a significant association between C-reactive protein with carditis and AOST (p-value = 0.020 and 0.014, respectively). Conclusion: ASOT and CRP are important laboratory parameters reflecting undergoing infection (mainly caused by Streptococcus pyogenes A) and inflammation in patients of ARF. Rising levels of ASOT and CRP in ARF patients might be used as an indicator of involvement of heart tissues and therefore can be used to monitor transition of rheumatic carditis into Rheumatic heart disease.

Author Biographies

Sana Zainab, Pakistan Kidney and Liver institute and Research Center Lahore.

M.Phil (Immunology)

Assistant Manager Immunology

 

Nida Saleem, Pakistan Kidney and Liver institute and Research Center Lahore.

MBBS, FCPS (Immunology)

Consultant Immunology

Adil Manzoor, Pakistan Kidney and Liver institute and Research Center Lahore.

FCPS, MRCP, FPRCP

Consultant Nephrology

 

Saba Khaliq, University of Health Sciences Lahore.

Ph.D Molecular Biology

Assistant Professor Physiology & Cell Biology

Anum Wasim, Pakistan Kidney and Liver institute and Research Center Lahore.

MBBS, FCPS (Hematology)

Senior Registrar

Shakila Khaliq, Rahim Yar Khan.

BSc. (Hons) Medical Laboratory Technology

Lecturer

 

Farhana Shehzad, The Children's Hospital and Institute of Child Health.

MBBS, M.Phil (Immunology)

Assistant Professor Immunology

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Published

2020-07-10