HYPERLIPIDEMIC PATIENTS;

COMPARISION OF EFFECETS OF STATIN AND NIACIN STATIN COMBANITION, ON APOLIPOPROTEIN-B LEVEL IN HYPERLIPIDEMIC PATIENTS.

  • Marium Shoukat CMH Multan Institute of Medical Science.
  • Hijab Batool Central Park Medical College, Lahore.
  • Faiza Javaid Sharif Medical and Dental College, Lahore.
Keywords: Statin, Niacin, Apo B, Atherosclerosis, Cardioprotective

Abstract

Objectives: Role of niacin in decreasing cardiovascular accidents by lowering the levels of Apo-B in hyperlipidemic patients. Background: In hyperlipidemia, there are high levels of atherogenic lipoproteins leading to higher risk of atherosclerotic cardiovascular events. Patients with dyslipidemia use statins as a mainstay of therapy over last many decades. Recent studies show that apolipoproteins play a major role in formation of atheromatous plaque, thus there is an urgent need to study the effects of lipid lowering medication on apolipoprotiens levels. Study Design: Cross sectional analytical study. Setting: Sheikh Zayed Hospital Lahore (Department of Biochemistry and Chemical Pathology). Period: 12 weeks from July to Sep 2014. Materials and Methods: Recently diagnosed hyperlipidemic patients (n=44) were selected for the study purpose and divided into two equal groups; A and B. Each group was given different medication. Group A took only statin while group B took a combination of statin and niacin. Blood samples were taken at the start of medication and then after completion of 12 week time period. Results: At the start of the treatment there was no significant difference in the Apo B cholesterol level between the two groups (p value 0.972). However, after the end of 12 week duration, there was a significant reduction in the Apo level of group B taking statin and niacin as compared to group A taking statin alone (p value 0.003). Conclusions: Niacin has cardio-protective role when used in combination with niacin.

Author Biographies

Marium Shoukat, CMH Multan Institute of Medical Science.

MBBS, M.Phil

Assistant Professor

Department of Biochemistry

 

Hijab Batool, Central Park Medical College, Lahore.

MBBS, M.Phil (Chemical Pathology)

Assistant Professor

Department of Chemical Pathology

 

Faiza Javaid, Sharif Medical and Dental College, Lahore.

MBBS, M.Phil (Chemical Pathology)

Assistant Professor

Department of Chemical Pathology

 

Published
2019-03-10