Effect of vitamin D supplementation on glycosylated hemoglobin in patients of type 2 diabetes mellitus taking oral antidiabetic drug metformin

  • Gunesh Kumar LUMHS, Jamshoro.
  • Jamil Laghari LUMHS Jamshoro.
  • Sadat Memon LUMHS, Jamshoro.
  • Nasreen Qazi LUMHS, Jamshoro.
  • Muhammad Yaqoob Shahani LUMHS, Jamshoro.
  • Shahnawaz Jamali Hamdard University Karachi.
Keywords: HbA1C, Type 2 Diabetes Mellitus, Vitamin D

Abstract

Objectives: To assess the outcome of vitamin D as adjunctive therapy in reducing the serum level of glycosylated hemoglobin (HbA1C) in type 2 diabetic patients taking anti-diabetic drug metformin. Study Design: An Observational study. Setting: This study was conducted at the Department of Pharmacology, Liaquat University of Medical and Health Sciences Jamshoro in collaboration with Sindh Institute of Endocrinology & Diabetes (SIED) Liaquat University of Medical and Health Sciences Jamshoro. Period: December 2017 to May 2018. Material and Methods: We carried out this study on 140 patients. Diagnosed patients of type 2 DM With duration more than 5 years, age between 35 to 60 years, HbA1c equal to or more than 6.0%, and diabetic patients which were on metformin and had vitamin D deficiency (level less than 30ng/ml) were included in the study. Results: Total 140 type 2 diabetic patients were taken in study. At baseline, in Group B, mean HbA1c ± SD was 7.92±1.54 while at 3 months intervention, in Group B, mean HbA1c ± SD was 7.18±1.53. No significant difference in HbA1c between Group A and B at baseline and after three months of intervention (P value = 0.46). The mean value of vitamin D before supplementation was 16.23±3.45 vs 28.96±5.25 after 3 months supplementation. There was a significant increase in 25 (OH) D levels after vitamin D supplementation after 3 months. (P < 0.0001). Conclusion: Supplementation of vitamin D did not show any effect on blood sugar control in our patients with type 2 DM.

Author Biographies

Gunesh Kumar, LUMHS, Jamshoro.

MBBS, M.Phil

Lecturer

Department of Pharmacology

 

Jamil Laghari, LUMHS Jamshoro.

MBBS, M.Phil
Assistant professor
Department of Pharmacology

Sadat Memon, LUMHS, Jamshoro.

MBBS, M.Phil
Lecturer 
Department of Pharmacology

Nasreen Qazi, LUMHS, Jamshoro.

MBBS, M.Phil, PhD

Department of Pharmacology

Muhammad Yaqoob Shahani, LUMHS, Jamshoro.

MBBS, D. Ophth., PhD 
Lecturer 
Department of Anatomy

Shahnawaz Jamali, Hamdard University Karachi.

MBBS, M.Phil, PhD 
Department of Pharmacology

Published
2019-10-07